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10.1128/JVI.01105-15

http://scihub22266oqcxt.onion/10.1128/JVI.01105-15
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C4524072!4524072!26085169
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suck abstract from ncbi


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pmid26085169      J+Virol 2015 ; 89 (17): 9124-7
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  • Preliminary Evaluation of a Bunyavirus Vector for Cancer Immunotherapy #MMPMID26085169
  • Oreshkova N; Spel L; Vloet RPM; Wichgers Schreur PJ; Moormann RJM; Boes M; Kortekaas J
  • J Virol 2015[Sep]; 89 (17): 9124-7 PMID26085169show ga
  • Replicon particles of Rift Valley fever virus, referred to as nonspreading Rift Valley fever virus (NSR), are intrinsically safe and highly immunogenic. Here, we demonstrate that NSR-infected human dendritic cells can activate CD8+ T cells in vitro and that prophylactic and therapeutic vaccinations of mice with NSR encoding a tumor-associated CD8 peptide can control the outgrowth of lymphoma cells in vivo. These results suggest that the NSR system holds promise for cancer immunotherapy.
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