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2015 ; 9
(ä): 111
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Understanding how discrete populations of hypothalamic neurons orchestrate
complicated behavioral states
#MMPMID26300745
Graebner AK
; Iyer M
; Carter ME
Front Syst Neurosci
2015[]; 9
(ä): 111
PMID26300745
show ga
A major question in systems neuroscience is how a single population of neurons
can interact with the rest of the brain to orchestrate complex behavioral states.
The hypothalamus contains many such discrete neuronal populations that
individually regulate arousal, feeding, and drinking. For example, hypothalamic
neurons that express hypocretin (Hcrt) neuropeptides can sense homeostatic and
metabolic factors affecting wakefulness and orchestrate organismal arousal.
Neurons that express agouti-related protein (AgRP) can sense the metabolic needs
of the body and orchestrate a state of hunger. The organum vasculosum of the
lamina terminalis (OVLT) can detect the hypertonicity of blood and orchestrate a
state of thirst. Each hypothalamic population is sufficient to generate
complicated behavioral states through the combined efforts of distinct efferent
projections. The principal challenge to understanding these brain systems is
therefore to determine the individual roles of each downstream projection for
each behavioral state. In recent years, the development and application of
temporally precise, genetically encoded tools has greatly improved our
understanding of the structure and function of these neural systems. This review
will survey recent advances in our understanding of how these individual
hypothalamic populations can orchestrate complicated behavioral states due to the
combined efforts of individual downstream projections.