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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Biochim+Biophys+Acta 2015 ; 1853 (9): 1953-7 Nephropedia Template TP
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Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus #MMPMID25700840
Ma H; Li B; Tsien RW
Biochim Biophys Acta 2015[Sep]; 1853 (9): 1953-7 PMID25700840show ga
Long-lasting synaptic changes following information acquisition are critical steps for memory. In this process, long-term potentiation (LTP) is widely considered as one of the major cellular mechanisms modifying synaptic strength. It can be classified into early phase LTP (E-LTP) and late phase LTP (L-LTP) based on its duration. Using genetically modified mice, investigators have recognized the critical role of CaMKII in E-LTP and memory. However, its function in L-LTP, which is strongly dependent on gene transcription and protein synthesis, is still unclear. In this review, we discuss how different isoforms of CaMKII are coordinated to regulate gene expression in an activity-dependent manner, and thus contribute to L-LTP and memory.