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Nuclear envelope: positioning nuclei and organizing synapses #MMPMID26079712
Razafsky D; Hodzic D
Curr Opin Cell Biol 2015[Jun]; 34 (ä): 84-93 PMID26079712show ga
The nuclear envelope plays an essential role in nuclear positioning within cells and tissues. This review highlights advances in understanding the mechanisms of nuclear positioning during skeletal muscle and central nervous system development. New findings, particularly about Atype lamins and Nesprin1, may link nuclear envelope integrity to synaptic integrity. Thus synaptic defects, rather than nuclear mispositioning, may underlie human pathologies associated with mutations of nuclear envelope proteins.