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2014 ; 2
(4
): 259-65
Nephropedia Template TP
gab.com Text
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Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B
Virus: What is New?
#MMPMID26356785
Harmanc? Ö
; Selçuk H
; Haberal M
J Clin Transl Hepatol
2014[Dec]; 2
(4
): 259-65
PMID26356785
show ga
Hepatitis B virus (HBV) causes an endemic infection that affects nearly 2 billion
patients worldwide. It is one of the leading causes of liver cirrhosis,
hepatocellular carcinoma (HCC), and liver transplantation (LT). Recurrence of HBV
infection after LT is due to specific HBV-host genome interactions. Although
hepatitis B immunoglobulin treatment constituted the backbone of HBV recurrence,
use of the nucleoside and nucleotide analogs (especially the ones with a higher
genetic barrier to resistance), either alone or in combination, offer us new and
powerful options in overcoming this serious issue.