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10.1002/wnan.1337

http://scihub22266oqcxt.onion/10.1002/wnan.1337
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C4520803!4520803!25645081
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suck abstract from ncbi


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pmid25645081      Wiley+Interdiscip+Rev+Nanomed+Nanobiotechnol 2015 ; 7 (6): 828-38
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  • NIR Fluorescent Small Molecules for Intraoperative Imaging #MMPMID25645081
  • Owens EA; Lee S; Choi J; Henary M; Choi HS
  • Wiley Interdiscip Rev Nanomed Nanobiotechnol 2015[Nov]; 7 (6): 828-38 PMID25645081show ga
  • Recent advances in bioimaging and nanomedicine have permitted the exploitation of molecular optical imaging in image-guided surgery; however, the parameters mediating optimum performance of contrast agents are not yet precisely determined. To develop ideal contrast agents for image-guided surgery, we need to consider the following criteria: 1) excitation and emission wavelengths in the NIR window, 2) optimized optical characteristics for high in vivo performance, 3) overcoming or harnessing biodistribution and clearance, and 4) reducing nonspecific uptake. The design considerations should be focused on optimizing the optical and physicochemical property criteria. Biodistribution and clearance should first be considered because they mediate the fate of a contrast agent in the body such as how long after intravenous injection a contrast agent reaches the peak signal-to-background ratio (SBR) and how long the signal lasts (retention).
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