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10.3390/jcdd2010002 http://scihub22266oqcxt.onion/10.3390/jcdd2010002 C4520698!4520698!26236710     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cardiovasc+Dev+Dis 2015 ; 2 (1): 2-16 Nephropedia Template TP {{tp|p=26236710|t=2015. Cellular Mechanisms of Drosophila Heart Morphogenesis |pdf=|usr=}}{{26236710}} gab.com Text Cellular Mechanisms of Drosophila Heart Morphogenesis JO: J Cardiovasc Dev Dis http://www.kidney.de/pget.php?&tw=1&pmid=26236710 #FOAvip Many of the major discoveries in the fields of genetics and developmental biology have been made using the fruit fly, Drosophila melanogaster. With regard to heart development, the conserved network of core cardiac transcription factors that underlies cardiogenesis has been studied in great detail in the fly, and the importance of several signaling pathways that regulate heart morphogenesis, such as Slit/Robo, was first shown in the fly model. Recent technological advances have led to a large increase in the genomic data available from patients with congenital heart disease (CHD). This has highlighted a number of candidate genes and gene networks that are potentially involved in CHD. To validate genes and genetic interactions among candidate CHD-causing alleles and to better understand heart formation in general are major tasks. The specific limitations of the various cardiac model systems currently employed (mammalian and fish models) provide a niche for the fly model, despite its evolutionary distance to vertebrates and humans. Here, we review recent advances made using the Drosophila embryo that identify factors relevant for heart formation. These underline how this model organism still is invaluable for a better understanding of CHD. Twit Text FOAVip Cellular Mechanisms of Drosophila Heart Morphogenesis ????J Cardiovasc Dev Dis http://www.kidney.de/pget.php?&tw=1&pmid=26236710 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26236710 #FOAvip English Wikipedia <ref>{{Cite pmid|26236710}}</ref> Cellular Mechanisms of Drosophila Heart Morphogenesis #MMPMID26236710 Vogler G; Bodmer R J Cardiovasc Dev Dis 2015[Mar]; 2 (1): 2-16 PMID26236710show ga Many of the major discoveries in the fields of genetics and developmental biology have been made using the fruit fly, Drosophila melanogaster. With regard to heart development, the conserved network of core cardiac transcription factors that underlies cardiogenesis has been studied in great detail in the fly, and the importance of several signaling pathways that regulate heart morphogenesis, such as Slit/Robo, was first shown in the fly model. Recent technological advances have led to a large increase in the genomic data available from patients with congenital heart disease (CHD). This has highlighted a number of candidate genes and gene networks that are potentially involved in CHD. To validate genes and genetic interactions among candidate CHD-causing alleles and to better understand heart formation in general are major tasks. The specific limitations of the various cardiac model systems currently employed (mammalian and fish models) provide a niche for the fly model, despite its evolutionary distance to vertebrates and humans. Here, we review recent advances made using the Drosophila embryo that identify factors relevant for heart formation. These underline how this model organism still is invaluable for a better understanding of CHD. äCellular Mechanisms of Drosophila Heart Morphogenesis (epmc).pdf DeepDyve Pubget Overpricing