Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25911996
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25911996
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cancer+Sci
2015 ; 106
(7
): 909-20
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for
target pathway evaluation
#MMPMID25911996
Mashima T
; Ushijima M
; Matsuura M
; Tsukahara S
; Kunimasa K
; Furuno A
; Saito S
; Kitamura M
; Soma-Nagae T
; Seimiya H
; Dan S
; Yamori T
; Tomida A
Cancer Sci
2015[Jul]; 106
(7
): 909-20
PMID25911996
show ga
Targeted therapy is a rational and promising strategy for the treatment of
advanced cancer. For the development of clinical agents targeting oncogenic
signaling pathways, it is important to define the specificity of compounds to the
target molecular pathway. Genome-wide transcriptomic analysis is an unbiased
approach to evaluate the compound mode of action, but it is still unknown whether
the analysis could be widely applicable to classify molecularly targeted
anticancer agents. We comprehensively obtained and analyzed 129 transcriptomic
datasets of cancer cells treated with 83 anticancer drugs or related agents,
covering most clinically used, molecularly targeted drugs alongside promising
inhibitors of molecular cancer targets. Hierarchical clustering and principal
component analysis revealed that compounds targeting similar target molecules or
pathways were clustered together. These results confirmed that the gene
signatures of these drugs reflected their modes of action. Of note, inhibitors of
oncogenic kinase pathways formed a large unique cluster, showing that these
agents affect a shared molecular pathway distinct from classical antitumor agents
and other classes of agents. The gene signature analysis further classified
kinome-targeting agents depending on their target signaling pathways, and we
identified target pathway-selective signature gene sets. The gene expression
analysis was also valuable in uncovering unexpected target pathways of some
anticancer agents. These results indicate that comprehensive transcriptomic
analysis with our database (http://scads.jfcr.or.jp/db/cs/) is a powerful
strategy to validate and re-evaluate the target pathways of anticancer compounds.
free
free
free
