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10.1186/s12883-015-0376-3 http://scihub22266oqcxt.onion/10.1186/s12883-015-0376-3 C4520077!4520077!26224123     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Neurol 2015 ; 15 (ä): ä Nephropedia Template TP {{tp|p=26224123|t=2015. Effect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study |pdf=|usr=}}{{26224123}} gab.com Text Effect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study JO: BMC Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26224123 #FOAvip Background: Experimental studies suggest that pre-stroke statin treatment has a dual effect of neuroprotection during ischemia and neurorestoration after ischemic injury. The aim of this study was to evaluate the effect of pre-stroke statin use on initial stroke severity and early clinical outcome. Methods: We used a prospective database enrolling patients with acute ischemic stroke from 12 hospitals in Korea between April 2008 and January 2012. Primary endpoint was the initial stroke severity as measured by the National Institutes of Health Stroke Scale (NIHSS) score. Secondary endpoints were good outcome (modified Rankin Scale [mRS], 0?2) and overall mRS distribution at discharge. Multivariable regression model and propensity score (PS) matching were used for statistical analyses. Results: Among the 8340 patients included in this study, 964 patients (11.6 %) were pre-stroke statin users. The initial NIHSS score (mean [95 % CI]) was lower among pre-stroke statin users vs. non-users in multivariable analysis (5.7 [5.2?6.3] versus 6.4 [5.9?6.9], p?=?0.002) and PS analysis (5.2 [4.7?5.7] versus 5.7 [5.4?6.0], p?=?0.043). Pre-stroke statin use was associated with increased achievement of mRS 0?2 outcome (multivariable analysis: OR [95 % CI], 1.55 [1.25?1.92], p?<?0.001; PS matching: OR [95 % CI], 1.47 [1.16-1.88]; p?=?0.002) and favorable shift on the overall mRS distribution (multivariable analysis: OR [95 % CI], 1.29 [1.12-1.51], p?=?0.001; PS matching: OR [95 % CI], 1.31 [1.11-1.54]; p?=?0.001). Conclusions: Pre-stroke statin use was independently associated with lesser stroke severity at presentation and better early functional recovery in patients with acute ischemic stroke. Electronic supplementary material: The online version of this article (doi:10.1186/s12883-015-0376-3) contains supplementary material, which is available to authorized users. Twit Text FOAVip Effect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study ????BMC Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26224123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26224123 #FOAvip English Wikipedia <ref>{{Cite pmid|26224123}}</ref> Effect of pre-stroke statin use on stroke severity and early functional recovery: a retrospective cohort study #MMPMID26224123 Choi JC; Lee JS; Park TH; Cho YJ; Park JM; Kang K; Lee KB; Lee SJ; Ko Y; Lee J; Kim JT; Yu KH; Lee BC; Cha JK; Kim DH; Lee J; Kim DE; Jang MS; Kim BJ; Han MK; Bae HJ; Hong KS BMC Neurol 2015[]; 15 (ä): ä PMID26224123show ga Background: Experimental studies suggest that pre-stroke statin treatment has a dual effect of neuroprotection during ischemia and neurorestoration after ischemic injury. The aim of this study was to evaluate the effect of pre-stroke statin use on initial stroke severity and early clinical outcome. Methods: We used a prospective database enrolling patients with acute ischemic stroke from 12 hospitals in Korea between April 2008 and January 2012. Primary endpoint was the initial stroke severity as measured by the National Institutes of Health Stroke Scale (NIHSS) score. Secondary endpoints were good outcome (modified Rankin Scale [mRS], 0?2) and overall mRS distribution at discharge. Multivariable regression model and propensity score (PS) matching were used for statistical analyses. Results: Among the 8340 patients included in this study, 964 patients (11.6 %) were pre-stroke statin users. The initial NIHSS score (mean [95 % CI]) was lower among pre-stroke statin users vs. non-users in multivariable analysis (5.7 [5.2?6.3] versus 6.4 [5.9?6.9], p?=?0.002) and PS analysis (5.2 [4.7?5.7] versus 5.7 [5.4?6.0], p?=?0.043). Pre-stroke statin use was associated with increased achievement of mRS 0?2 outcome (multivariable analysis: OR [95 % CI], 1.55 [1.25?1.92], p? äEffect of pre-stroke statin use on stroke severity and early functiona(epmc).pdf DeepDyve Pubget Overpricing