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10.1371/journal.pone.0134326 http://scihub22266oqcxt.onion/10.1371/journal.pone.0134326 C4519308!4519308!26221731     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (7): ä Nephropedia Template TP {{tp|p=26221731|t=2015. A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity |pdf=|usr=}}{{26221731}} gab.com Text A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26221731 #FOAvip We identified Mrpl44 in a search for mammalian proteins that contain RNase III domains. This protein was previously found in association with the mitochondrial ribosome of bovine liver extracts. However, the precise Mrpl44 localization had been unclear. Here, we show by immunofluorescence microscopy and subcellular fractionation that Mrpl44 is localized to the matrix of the mitochondria. We found that it can form multimers, and confirm that it is part of the large subunit of the mitochondrial ribosome. By manipulating its expression, we show that Mrpl44 may be important for regulating the expression of mtDNA-encoded genes. This was at the level of RNA expression and protein translation. This ultimately impacted ATP synthesis capability and respiratory capacity of cells. These findings indicate that Mrpl44 plays an important role in the regulation of the mitochondrial OXPHOS capacity. Twit Text FOAVip A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26221731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26221731 #FOAvip English Wikipedia <ref>{{Cite pmid|26221731}}</ref> A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity #MMPMID26221731 Yeo JHC; Skinner JPJ; Bird MJ; Formosa LE; Zhang JG; Kluck RM; Belz GT; Chong MMW PLoS One 2015[]; 10 (7): ä PMID26221731show ga We identified Mrpl44 in a search for mammalian proteins that contain RNase III domains. This protein was previously found in association with the mitochondrial ribosome of bovine liver extracts. However, the precise Mrpl44 localization had been unclear. Here, we show by immunofluorescence microscopy and subcellular fractionation that Mrpl44 is localized to the matrix of the mitochondria. We found that it can form multimers, and confirm that it is part of the large subunit of the mitochondrial ribosome. By manipulating its expression, we show that Mrpl44 may be important for regulating the expression of mtDNA-encoded genes. This was at the level of RNA expression and protein translation. This ultimately impacted ATP synthesis capability and respiratory capacity of cells. These findings indicate that Mrpl44 plays an important role in the regulation of the mitochondrial OXPHOS capacity. äA Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capa(epmc).pdf DeepDyve Pubget Overpricing