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10.1126/science.1257861 http://scihub22266oqcxt.onion/10.1126/science.1257861 C4519234!4519234!25170154     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2014 ; 345 (6200): 1058-62 Nephropedia Template TP {{tp|p=25170154|t=2014. Dynamic signaling by T follicular helper cells during germinal center B cell selection |pdf=|usr=}}{{25170154}} gab.com Text Dynamic signaling by T follicular helper cells during germinal center B cell selection JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25170154 #FOAvip T follicular helper (TFH) cells select high-affinity, antibody-producing B cells for clonal expansion in germinal centers (GCs), but the nature of their interaction is not well defined. Using intravital imaging, we found that selection is mediated by large but transient contacts between TFH and GC B cells presenting the highest levels of cognate peptide bound to major histocompatibility complex II. These interactions elicited transient and sustained increases in TFH intracellular free calcium (Ca2+) that were associated with TFH cell coexpression of the cytokines interleukin-4 and -21. However, increased intracellular Ca2+ did not arrest TFH cell migration. Instead, TFH cells remained motile and continually scanned the surface of many GC B cells, forming short-lived contacts that induced selection through further repeated transient elevations in intracellular Ca2+. Twit Text FOAVip Dynamic signaling by T follicular helper cells during germinal center B cell selection ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25170154 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25170154 #FOAvip English Wikipedia <ref>{{Cite pmid|25170154}}</ref> Dynamic signaling by T follicular helper cells during germinal center B cell selection #MMPMID25170154 Shulman Z; Gitlin AD; Weinstein JS; Lainez B; Esplugues E; Flavell RA; Craft JE; Nussenzweig MC Science 2014[Aug]; 345 (6200): 1058-62 PMID25170154show ga T follicular helper (TFH) cells select high-affinity, antibody-producing B cells for clonal expansion in germinal centers (GCs), but the nature of their interaction is not well defined. Using intravital imaging, we found that selection is mediated by large but transient contacts between TFH and GC B cells presenting the highest levels of cognate peptide bound to major histocompatibility complex II. These interactions elicited transient and sustained increases in TFH intracellular free calcium (Ca2+) that were associated with TFH cell coexpression of the cytokines interleukin-4 and -21. However, increased intracellular Ca2+ did not arrest TFH cell migration. Instead, TFH cells remained motile and continually scanned the surface of many GC B cells, forming short-lived contacts that induced selection through further repeated transient elevations in intracellular Ca2+. äDynamic signaling by T follicular helper cells during germinal center (epmc).pdf DeepDyve Pubget Overpricing