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10.1371/journal.pone.0133981

http://scihub22266oqcxt.onion/10.1371/journal.pone.0133981
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C4519191!4519191!26221724
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suck abstract from ncbi


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pmid26221724      PLoS+One 2015 ; 10 (7): ä
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  • Feasibility of a Short-Arm Centrifuge for Mouse Hypergravity Experiments #MMPMID26221724
  • Morita H; Obata K; Abe C; Shiba D; Shirakawa M; Kudo T; Takahashi S
  • PLoS One 2015[]; 10 (7): ä PMID26221724show ga
  • To elucidate the pure impact of microgravity on small mammals despite uncontrolled factors that exist in the International Space Station, it is necessary to construct a 1 g environment in space. The Japan Aerospace Exploration Agency has developed a novel mouse habitat cage unit that can be installed in the Cell Biology Experiment Facility in the Kibo module of the International Space Station. The Cell Biology Experiment Facility has a short-arm centrifuge to produce artificial 1 g gravity in space for mouse experiments. However, the gravitational gradient formed inside the rearing cage is larger when the radius of gyration is shorter; this may have some impact on mice. Accordingly, biological responses to hypergravity induced by a short-arm centrifuge were examined and compared with those induced by a long-arm centrifuge. Hypergravity induced a significant Fos expression in the central nervous system, a suppression of body mass growth, an acute and transient reduction in food intake, and impaired vestibulomotor coordination. There was no difference in these responses between mice raised in a short-arm centrifuge and those in a long-arm centrifuge. These results demonstrate the feasibility of using a short-arm centrifuge for mouse experiments.
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