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10.1146/annurev-genom-082410-101412 http://scihub22266oqcxt.onion/10.1146/annurev-genom-082410-101412 C4519033!4519033!21756106     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Genomics+Hum+Genet 2011 ; 12 (ä): 347-66 Nephropedia Template TP {{tp|p=21756106|t=2011. The Repatterning of Eukaryotic Genomes by Random Genetic Drift |pdf=|usr=}}{{21756106}} gab.com Text The Repatterning of Eukaryotic Genomes by Random Genetic Drift JO: Annu Rev Genomics Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=21756106 #FOAvip Recent observations on rates of mutation, recombination, and random genetic drift highlight the dramatic ways in which fundamental evolutionary processes vary across the divide between unicellular microbes and multicellular eukaryotes. Moreover, population-genetic theory suggests that the range of variation in these parameters is sufficient to explain the evolutionary diversification of many aspects of genome size and gene structure found among phylogenetic lineages. Most notably, large eukaryotic organisms that experience elevated magnitudes of random genetic drift are susceptible to the passive accumulation of mutationally hazardous DNA that would otherwise be eliminated by efficient selection. Substantial evidence also suggests that variation in the population-genetic environment influences patterns of protein evolution, with the emergence of certain kinds of amino-acid substitutions and protein-protein complexes only being possible in populations with relatively small effective sizes. These observations imply that the ultimate origins of many of the major genomic and proteomic disparities between prokaryotes and eukaryotes and among eukaryotic lineages have been molded as much by intrinsic variation in the genetic and cellular features of species as by external ecological forces. Twit Text FOAVip The Repatterning of Eukaryotic Genomes by Random Genetic Drift ????Annu Rev Genomics Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=21756106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21756106 #FOAvip English Wikipedia <ref>{{Cite pmid|21756106}}</ref> The Repatterning of Eukaryotic Genomes by Random Genetic Drift #MMPMID21756106 Lynch M; Bobay LM; Catania F; Gout JF; Rho M Annu Rev Genomics Hum Genet 2011[]; 12 (ä): 347-66 PMID21756106show ga Recent observations on rates of mutation, recombination, and random genetic drift highlight the dramatic ways in which fundamental evolutionary processes vary across the divide between unicellular microbes and multicellular eukaryotes. Moreover, population-genetic theory suggests that the range of variation in these parameters is sufficient to explain the evolutionary diversification of many aspects of genome size and gene structure found among phylogenetic lineages. Most notably, large eukaryotic organisms that experience elevated magnitudes of random genetic drift are susceptible to the passive accumulation of mutationally hazardous DNA that would otherwise be eliminated by efficient selection. Substantial evidence also suggests that variation in the population-genetic environment influences patterns of protein evolution, with the emergence of certain kinds of amino-acid substitutions and protein-protein complexes only being possible in populations with relatively small effective sizes. These observations imply that the ultimate origins of many of the major genomic and proteomic disparities between prokaryotes and eukaryotes and among eukaryotic lineages have been molded as much by intrinsic variation in the genetic and cellular features of species as by external ecological forces. äThe Repatterning of Eukaryotic Genomes by Random Genetic Drift (epmc).pdf DeepDyve Pubget Overpricing