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10.1186/s12882-015-0113-6 http://scihub22266oqcxt.onion/10.1186/s12882-015-0113-6 C4519001!4519001 !26220655     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26220655 &cmd=llinks): Failed to open stream: HTTP request failed! 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Rhabdomyolysis-induced acute kidney injury in a cancer patient exposed to denosumab and abiraterone: a case report |pdf=|usr=}}{{26220655 }} gab.com Text Rhabdomyolysis-induced acute kidney injury in a cancer patient exposed to denosumab and abiraterone: a case report JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26220655 #FOAvip BACKGROUND: Denosumab and abiraterone were approved by the United States Food and Drug Administration in 2011 for the treatment of metastatic castration-resistant prostate cancer. Neither denosumab nor abiraterone is known to cause rhabdomyolysis. CASE PRESENTATION: A 76-year-old Caucasian man with metastatic prostate cancer presented with non-oliguric severe acute kidney injury (AKI) 3 weeks after receiving simultaneous therapy with denosumab and abiraterone. The patient had been on statin therapy for more than 1 year with no recent dose adjustments. His physical exam was unremarkable. Blood work on admission revealed hyperkalemia, mild metabolic acidosis, hypocalcemia, and elevated creatine kinase (CK) at 44,476 IU/L. Kidney biopsy confirmed the diagnosis of rhabdomyolysis-induced AKI. The patient responded well to intravenous isotonic fluids and discontinuation of denosumab, abiraterone, and rosuvastatin, with normalization of CK and recovery of kidney function. CONCLUSION: We report the first case of biopsy-proven rhabdomyolysis-induced AKI in a cancer patient acutely exposed to denosumab and abiraterone. Whether one of these drugs individually, or the combination, was the bona fide culprit of muscle breakdown is unknown. Nonetheless, our report is hypothesis-generating for further investigations on the effect of these drugs on muscle cells. Twit Text FOAVip Rhabdomyolysis-induced acute kidney injury in a cancer patient exposed to denosumab and abiraterone: a case report ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26220655 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26220655 #FOAvip English Wikipedia <ref>{{Cite pmid|26220655 }}</ref> Rhabdomyolysis-induced acute kidney injury in a cancer patient exposed to denosumab and abiraterone: a case report #MMPMID26220655 Neyra JA ; Rocha NA ; Bhargava R ; Vaidya OU ; Hendricks AR ; Rodan AR BMC Nephrol 2015[Jul]; 16 (ä): 118 PMID26220655 show ga BACKGROUND: Denosumab and abiraterone were approved by the United States Food and Drug Administration in 2011 for the treatment of metastatic castration-resistant prostate cancer. Neither denosumab nor abiraterone is known to cause rhabdomyolysis. CASE PRESENTATION: A 76-year-old Caucasian man with metastatic prostate cancer presented with non-oliguric severe acute kidney injury (AKI) 3 weeks after receiving simultaneous therapy with denosumab and abiraterone. The patient had been on statin therapy for more than 1 year with no recent dose adjustments. His physical exam was unremarkable. Blood work on admission revealed hyperkalemia, mild metabolic acidosis, hypocalcemia, and elevated creatine kinase (CK) at 44,476 IU/L. Kidney biopsy confirmed the diagnosis of rhabdomyolysis-induced AKI. The patient responded well to intravenous isotonic fluids and discontinuation of denosumab, abiraterone, and rosuvastatin, with normalization of CK and recovery of kidney function. CONCLUSION: We report the first case of biopsy-proven rhabdomyolysis-induced AKI in a cancer patient acutely exposed to denosumab and abiraterone. Whether one of these drugs individually, or the combination, was the bona fide culprit of muscle breakdown is unknown. Nonetheless, our report is hypothesis-generating for further investigations on the effect of these drugs on muscle cells. |Acute Kidney Injury/*etiology [MESH] |Aged [MESH] |Androstenes/*administration & dosage [MESH] |Antineoplastic Combined Chemotherapy Protocols/*administration & dosage [MESH] |Denosumab/*administration & dosage [MESH] |Humans [MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use [MESH] |Male [MESH] |Prostatic Neoplasms, Castration-Resistant/*drug therapy/pathology [MESH] |Rhabdomyolysis/*complications [MESH]Rhabdomyolysis-induced acute kidney injury in a cancer patient exposed(epmc).pdf DeepDyve Pubget Overpricing