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10.1186/s40478-015-0225-z http://scihub22266oqcxt.onion/10.1186/s40478-015-0225-z C4518593!4518593!26220190     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neuropathol+Commun 2015 ; 3 (ä): ä Nephropedia Template TP {{tp|p=26220190|t=2015. Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase |pdf=|usr=}}{{26220190}} gab.com Text Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase JO: Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=26220190 #FOAvip Introduction: Tuberous sclerosis complex (TSC) is a genetic disease resulting from mutation in TSC1 or TSC2 and subsequent hyperactivation of mammalian Target of Rapamycin (mTOR). Common TSC features include brain lesions, such as cortical tubers and subependymal giant cell astrocytomas (SEGAs). However, the current treatment with mTOR inhibitors has critical limitations. We aimed to identify new targets for TSC pharmacotherapy. Results: The results of our shRNA screen point to glutamate-cysteine ligase catalytic subunit (GCLC), a key enzyme in glutathione synthesis, as a contributor to TSC-related phenotype. GCLC inhibition increased cellular stress and reduced mTOR hyperactivity in TSC2-depleted neurons and SEGA-derived cells. Moreover, patients? brain tubers showed elevated GCLC and stress markers expression. Finally, GCLC inhibition led to growth arrest and death of SEGA-derived cells. Conclusions: We describe GCLC as a part of redox adaptation in TSC, needed for overgrowth and survival of mutant cells, and provide a potential novel target for SEGA treatment. Electronic supplementary material: The online version of this article (doi:10.1186/s40478-015-0225-z) contains supplementary material, which is available to authorized users. Twit Text FOAVip Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase ????Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=26220190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26220190 #FOAvip English Wikipedia <ref>{{Cite pmid|26220190}}</ref> Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase #MMPMID26220190 Malik AR; Liszewska E; Skalecka A; Urbanska M; Iyer AM; Swiech LJ; Perycz M; Parobczak K; Pietruszka P; Zarebska MM; Macias M; Kotulska K; Borkowska J; Grajkowska W; Tyburczy ME; Jozwiak S; Kwiatkowski DJ; Aronica E; Jaworski J Acta Neuropathol Commun 2015[]; 3 (ä): ä PMID26220190show ga Introduction: Tuberous sclerosis complex (TSC) is a genetic disease resulting from mutation in TSC1 or TSC2 and subsequent hyperactivation of mammalian Target of Rapamycin (mTOR). Common TSC features include brain lesions, such as cortical tubers and subependymal giant cell astrocytomas (SEGAs). However, the current treatment with mTOR inhibitors has critical limitations. We aimed to identify new targets for TSC pharmacotherapy. Results: The results of our shRNA screen point to glutamate-cysteine ligase catalytic subunit (GCLC), a key enzyme in glutathione synthesis, as a contributor to TSC-related phenotype. GCLC inhibition increased cellular stress and reduced mTOR hyperactivity in TSC2-depleted neurons and SEGA-derived cells. Moreover, patients? brain tubers showed elevated GCLC and stress markers expression. Finally, GCLC inhibition led to growth arrest and death of SEGA-derived cells. Conclusions: We describe GCLC as a part of redox adaptation in TSC, needed for overgrowth and survival of mutant cells, and provide a potential novel target for SEGA treatment. Electronic supplementary material: The online version of this article (doi:10.1186/s40478-015-0225-z) contains supplementary material, which is available to authorized users. äTuberous sclerosis complex neuropathology requires glutamate-cysteine (epmc).pdf DeepDyve Pubget Overpricing