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10.1186/s12872-015-0073-6 http://scihub22266oqcxt.onion/10.1186/s12872-015-0073-6 C4518524!4518524 !26223692     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26223692 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Cardiovasc+Disord 2015 ; 15 (ä): 79 Nephropedia Template TP {{tp|p=26223692 |t=2015. Admission hypoxia-inducible factor 1? levels and in-hospital mortality in patients with acute decompensated heart failure |pdf=|usr=}}{{26223692 }} gab.com Text Admission hypoxia-inducible factor 1 levels and in-hospital mortality in patients with acute decompensated heart failure JO: BMC Cardiovasc Disord http://www.kidney.de/pget.php?&tw=1&pmid=26223692 #FOAvip BACKGROUND: Hypoxia-inducible factor 1 (HIF-1) is a critical regulator for cellular oxygen balance. Myocardial hypoxia can induce the increased expression of HIF-1?. Our goals were to evaluate the value of HIF-1? in predicting death of patients with acute decompensated heart failure (ADHF) and describe the in vivo relationship between serum HIF-1? and N-terminal-pro-brain natriuretic peptide (NT-proBNP) levels. METHOD: We included 296 patients who were consecutively admitted to the emergency department for ADHF. The primary end point was in-hospital death. The patients were categorized as HFrEF (patients with reduced systolic function) and HFpEF (patients with preserved systolic function) groups. RESULTS: In our patients, the median admission HIF-1? level was 2.95?±?0.85 ng/ml. The HIF-1? level was elevated significantly in HFrEF patients and deceased patients compared with HFpEF patients and patients who survived. The HIF-1? level was positively correlated with NT-proBNP and cardiac troponin T levels, and negatively correlated with left ventricular ejection fraction and systolic blood pressure. Kaplan-Meier curves revealed a significant increase in in-hospital mortality in ADHF patients with higher HIF-1? levels. Multivariable Cox regression analysis showed that HIF-1? levels were not correlated with the short-term prognosis of ADHF patients. CONCLUSIONS: This is the first study to evaluate the circulating levels of HIF-1? in ADHF patients. Serum HIF-1? levels may reflect a serious state in patients with ADHF. Due to the limitations of the study, serum HIF-1? levels were not correlated with the in-hospital mortality based on regression analysis. Further studies are needed to demonstrate the diagnostic and/or prognostic role of HIF-1? as a risk biomarker in patients with ADHF. Twit Text FOAVip Admission hypoxia-inducible factor 1 levels and in-hospital mortality in patients with acute decompensated heart failure ????BMC Cardiovasc Disord http://www.kidney.de/pget.php?&tw=1&pmid=26223692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26223692 #FOAvip English Wikipedia <ref>{{Cite pmid|26223692 }}</ref> Admission hypoxia-inducible factor 1? levels and in-hospital mortality in patients with acute decompensated heart failure #MMPMID26223692 Li G ; Lu WH ; Wu XW ; Cheng J ; Ai R ; Zhou ZH ; Tang ZZ BMC Cardiovasc Disord 2015[Jul]; 15 (ä): 79 PMID26223692 show ga BACKGROUND: Hypoxia-inducible factor 1 (HIF-1) is a critical regulator for cellular oxygen balance. Myocardial hypoxia can induce the increased expression of HIF-1?. Our goals were to evaluate the value of HIF-1? in predicting death of patients with acute decompensated heart failure (ADHF) and describe the in vivo relationship between serum HIF-1? and N-terminal-pro-brain natriuretic peptide (NT-proBNP) levels. METHOD: We included 296 patients who were consecutively admitted to the emergency department for ADHF. The primary end point was in-hospital death. The patients were categorized as HFrEF (patients with reduced systolic function) and HFpEF (patients with preserved systolic function) groups. RESULTS: In our patients, the median admission HIF-1? level was 2.95?±?0.85 ng/ml. The HIF-1? level was elevated significantly in HFrEF patients and deceased patients compared with HFpEF patients and patients who survived. The HIF-1? level was positively correlated with NT-proBNP and cardiac troponin T levels, and negatively correlated with left ventricular ejection fraction and systolic blood pressure. Kaplan-Meier curves revealed a significant increase in in-hospital mortality in ADHF patients with higher HIF-1? levels. Multivariable Cox regression analysis showed that HIF-1? levels were not correlated with the short-term prognosis of ADHF patients. CONCLUSIONS: This is the first study to evaluate the circulating levels of HIF-1? in ADHF patients. Serum HIF-1? levels may reflect a serious state in patients with ADHF. Due to the limitations of the study, serum HIF-1? levels were not correlated with the in-hospital mortality based on regression analysis. Further studies are needed to demonstrate the diagnostic and/or prognostic role of HIF-1? as a risk biomarker in patients with ADHF. |Acute Disease [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Biomarkers/blood [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Heart Failure/*blood/diagnosis/*mortality [MESH] |Hospital Mortality/*trends [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*blood [MESH] |Male [MESH] |Middle Aged [MESH]Admission hypoxia-inducible factor 1? levels and in-hospital mortality(epmc).pdf DeepDyve Pubget Overpricing