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10.1016/j.semnephrol.2015.04.004 http://scihub22266oqcxt.onion/10.1016/j.semnephrol.2015.04.004 C4518207!4518207!26215862     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Semin+Nephrol 2015 ; 35 (3): 245-55 Nephropedia Template TP {{tp|p=26215862|t=2015. Podometrics as a potential clinical tool for glomerular disease management |pdf=|usr=}}{{26215862}} gab.com Text Podometrics as a potential clinical tool for glomerular disease management JO: Semin Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26215862 #FOAvip Chronic Kidney Disease culminating in End Stage Kidney Disease is a major public health problem costing in excess of $40 billion per year with high morbidity and mortality. Current tools for glomerular disease monitoring lack precision and contribute to poor outcome. The podocyte depletion hypothesis describes the major mechanisms underlying progression of glomerular diseases responsible for >80% of ESKD. The question arises whether this new knowledge can be used to improve outcomes and reduce costs. Podocytes have unique characteristics that make them an attractive monitoring tool. Methodologies for estimating podocyte number, size, density, glomerular volume and other parameters in routine kidney biopsies, and the rate of podocyte detachment from glomeruli into urine (?podometrics?), have now been developed and validated. They potentially fill important gaps in the glomerular disease monitoring toolbox. Application of these tools to glomerular disease groups demonstrates good correlation with outcome, although data validating their use for individual decision-making is not yet available. Given the urgency of the clinical problem we argue that the time has come to focus on testing these tools for application to individualized clinical decision-making towards more effective progression prevention. Twit Text FOAVip Podometrics as a potential clinical tool for glomerular disease management ????Semin Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26215862 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26215862 #FOAvip English Wikipedia <ref>{{Cite pmid|26215862}}</ref> Podometrics as a potential clinical tool for glomerular disease management #MMPMID26215862 Kikuchi M; Wickman L; Hodgin J; Wiggins RC Semin Nephrol 2015[May]; 35 (3): 245-55 PMID26215862show ga Chronic Kidney Disease culminating in End Stage Kidney Disease is a major public health problem costing in excess of $40 billion per year with high morbidity and mortality. Current tools for glomerular disease monitoring lack precision and contribute to poor outcome. The podocyte depletion hypothesis describes the major mechanisms underlying progression of glomerular diseases responsible for >80% of ESKD. The question arises whether this new knowledge can be used to improve outcomes and reduce costs. Podocytes have unique characteristics that make them an attractive monitoring tool. Methodologies for estimating podocyte number, size, density, glomerular volume and other parameters in routine kidney biopsies, and the rate of podocyte detachment from glomeruli into urine (?podometrics?), have now been developed and validated. They potentially fill important gaps in the glomerular disease monitoring toolbox. Application of these tools to glomerular disease groups demonstrates good correlation with outcome, although data validating their use for individual decision-making is not yet available. Given the urgency of the clinical problem we argue that the time has come to focus on testing these tools for application to individualized clinical decision-making towards more effective progression prevention. äPodometrics as a potential clinical tool for glomerular disease manage(epmc).pdf DeepDyve Pubget Overpricing