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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Semin+Nephrol
2015 ; 35
(3
): 237-44
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gab.com Text
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English Wikipedia
Genes Caught In Flagranti: Integrating Renal Transcriptional Profiles With
Genotypes and Phenotypes
#MMPMID26215861
Guan Y
; Martini S
; Mariani LH
Semin Nephrol
2015[May]; 35
(3
): 237-44
PMID26215861
show ga
In the past decade, population genetics has gained tremendous success in
identifying genetic variations that are statistically relevant to renal diseases
and kidney function. However, it is challenging to interpret the functional
relevance of the genetic variations found by population genetics studies. In this
review, we discuss studies that integrate multiple levels of data, especially
transcriptome profiles and phenotype data, to assign functional roles of genetic
variations involved in kidney function. Furthermore, we introduce
state-of-the-art machine learning algorithms, Bayesian networks, support vector
machines, and Gaussian process regression, which have been applied successfully
to integrating genetic, regulatory, and clinical information to predict clinical
outcomes. These methods are likely to be deployed successfully in the nephrology
field in the near future.