Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.mvr.2013.02.005 http://scihub22266oqcxt.onion/10.1016/j.mvr.2013.02.005 C4517969!4517969!23481864     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microvasc+Res 2013 ; 87 (ä): 58-64 Nephropedia Template TP {{tp|p=23481864|t=2013. Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans |pdf=|usr=}}{{23481864}} gab.com Text Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans JO: Microvasc Res http://www.kidney.de/pget.php?&tw=1&pmid=23481864 #FOAvip Essential hypertension (HT) is associated with endothelial dysfunction augmented vasoconstriction (VC) which may be secondary to increased Rho/Rho-Kinase (ROCK)-dependent mechanisms. Our aim was to assess the in vivo magnitude of cutaneous VC to local cooling as a ROCK specific stimulus, and in vitro evaluate ROCK activity in skin from HT humans. Four microdialysis fibers were placed in the forearm of 9 pre- to stage I hypertensive (MAP: 106 ± 3 mmHg) and 11 normotensive (NT; 86 ± 1 mmHg) men and women: Ringers (control), 3 mM fasudil (ROCK inhibited), 5 mM yohimbine + 1 mM proprananol (?- and ?-adrenoceptor inhibited; Y + P), Y + P + 3 mM fasudil (ROCK and adrenocepor inhibited). Skin blood flow was measured during local cooling (Tskl 24°C) and ROCK activity in skin biopsy samples was determined with western blot. In vitro phosphorylated myosin phosphatase target subunit 1 (pMYPT-1)/ROCK was increased in HT skin samples (p=0.0018). Functionally, no difference in basal vasomotor tone (Tskl 34°C) was observed between groups (HT: 0.36 ± 0.07 vs. NT: 0.31 ± 0.07 CVC), nor at the control site during local cooling. Pre- to stage 1 hypertensives show greater ROCK-mediated vasoconstriction at early (1?5 min; HT: ?0.8±0.2 versus NT: ?0.3±0.2 ?CVC baseline 1; P<0.0001) and late (36?40 min; HT: ?0.9±0.1 versus NT: ?0.5±0.2 ?CVC baseline 1; P<0.0001) phases of local cooling. These data suggest that the magnitude of cutaneous vasoconstriction to local cooling does not differ in normotensive and pre- to stage I essential hypertensive humans; however, ROCK activity is increased and functional vasoconstriction is increasingly dependent upon Rho/ROCK mechanisms with essential hypertension. Twit Text FOAVip Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans ????Microvasc Res http://www.kidney.de/pget.php?&tw=1&pmid=23481864 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23481864 #FOAvip English Wikipedia <ref>{{Cite pmid|23481864}}</ref> Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans #MMPMID23481864 Smith CJ; Santhanam L; Alexander LM Microvasc Res 2013[May]; 87 (ä): 58-64 PMID23481864show ga Essential hypertension (HT) is associated with endothelial dysfunction augmented vasoconstriction (VC) which may be secondary to increased Rho/Rho-Kinase (ROCK)-dependent mechanisms. Our aim was to assess the in vivo magnitude of cutaneous VC to local cooling as a ROCK specific stimulus, and in vitro evaluate ROCK activity in skin from HT humans. Four microdialysis fibers were placed in the forearm of 9 pre- to stage I hypertensive (MAP: 106 ± 3 mmHg) and 11 normotensive (NT; 86 ± 1 mmHg) men and women: Ringers (control), 3 mM fasudil (ROCK inhibited), 5 mM yohimbine + 1 mM proprananol (?- and ?-adrenoceptor inhibited; Y + P), Y + P + 3 mM fasudil (ROCK and adrenocepor inhibited). Skin blood flow was measured during local cooling (Tskl 24°C) and ROCK activity in skin biopsy samples was determined with western blot. In vitro phosphorylated myosin phosphatase target subunit 1 (pMYPT-1)/ROCK was increased in HT skin samples (p=0.0018). Functionally, no difference in basal vasomotor tone (Tskl 34°C) was observed between groups (HT: 0.36 ± 0.07 vs. NT: 0.31 ± 0.07 CVC), nor at the control site during local cooling. Pre- to stage 1 hypertensives show greater ROCK-mediated vasoconstriction at early (1?5 min; HT: ?0.8±0.2 versus NT: ?0.3±0.2 ?CVC baseline 1; P<0.0001) and late (36?40 min; HT: ?0.9±0.1 versus NT: ?0.5±0.2 ?CVC baseline 1; P<0.0001) phases of local cooling. These data suggest that the magnitude of cutaneous vasoconstriction to local cooling does not differ in normotensive and pre- to stage I essential hypertensive humans; however, ROCK activity is increased and functional vasoconstriction is increasingly dependent upon Rho/ROCK mechanisms with essential hypertension. äRho-Kinase activity and cutaneous vasoconstriction is upregulated in e(epmc).pdf DeepDyve Pubget Overpricing