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10.1371/journal.pone.0133567 http://scihub22266oqcxt.onion/10.1371/journal.pone.0133567 C4517900!4517900!26218245     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (7): ä Nephropedia Template TP {{tp|p=26218245|t=2015. Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation |pdf=|usr=}}{{26218245}} gab.com Text Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26218245 #FOAvip Primary Cilia (PC) are a very likely place for signal integration where multiple signaling pathways converge. Two major signaling pathways clearly shown to signal through the PC, Sonic Hedgehog (Shh) and PDGF-R?, are particularly important for the proliferation and differentiation of oligodendrocytes, suggesting that their interaction occurs in or around this organelle. We identified PC in rat oligodendrocyte precursor cells (OPCs) and found that, while easily detectable in early OPCs, PC are lost as these cells progress to terminal differentiation. We confirmed the interaction between these pathways, as cyclopamine inhibition of Hedgehog function impairs both PDGF-mediated OPC proliferation and Shh-dependent cell branching. However, we failed to detect PDGF-R? localization into the PC. Remarkably, ciliobrevin-mediated disruption of PC and reduction of OPC process extension was counteracted by recombinant Shh treatment, while PDGF had no effect. Therefore, while PDGF-R?-dependent OPC proliferation and survival most probably does not initiate at the PC, still the integrity of this organelle and cilium-centered pathway is necessary for OPC survival and differentiation. Twit Text FOAVip Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26218245 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26218245 #FOAvip English Wikipedia <ref>{{Cite pmid|26218245}}</ref> Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation #MMPMID26218245 Falcón-Urrutia P; Carrasco CM; Lois P; Palma V; Roth AD PLoS One 2015[]; 10 (7): ä PMID26218245show ga Primary Cilia (PC) are a very likely place for signal integration where multiple signaling pathways converge. Two major signaling pathways clearly shown to signal through the PC, Sonic Hedgehog (Shh) and PDGF-R?, are particularly important for the proliferation and differentiation of oligodendrocytes, suggesting that their interaction occurs in or around this organelle. We identified PC in rat oligodendrocyte precursor cells (OPCs) and found that, while easily detectable in early OPCs, PC are lost as these cells progress to terminal differentiation. We confirmed the interaction between these pathways, as cyclopamine inhibition of Hedgehog function impairs both PDGF-mediated OPC proliferation and Shh-dependent cell branching. However, we failed to detect PDGF-R? localization into the PC. Remarkably, ciliobrevin-mediated disruption of PC and reduction of OPC process extension was counteracted by recombinant Shh treatment, while PDGF had no effect. Therefore, while PDGF-R?-dependent OPC proliferation and survival most probably does not initiate at the PC, still the integrity of this organelle and cilium-centered pathway is necessary for OPC survival and differentiation. äShh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte(epmc).pdf DeepDyve Pubget Overpricing