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10.1186/s40200-015-0185-7 http://scihub22266oqcxt.onion/10.1186/s40200-015-0185-7 C4517497!4517497 !26221579     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26221579 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Diabetes+Metab+Disord 2015 ; 14 (ä): 63 Nephropedia Template TP {{tp|p=26221579 |t=2015. Combined effect of hydrogen sulphide donor and losartan in experimental diabetic nephropathy in rats |pdf=|usr=}}{{26221579 }} gab.com Text Combined effect of hydrogen sulphide donor and losartan in experimental diabetic nephropathy in rats JO: J Diabetes Metab Disord http://www.kidney.de/pget.php?&tw=1&pmid=26221579 #FOAvip BACKGROUND: Diabetic nephropathy (DN) is one of the complex complications of Diabetes Mellitus (DM). The present study has been designed to examine protective role of hydrogen Sulphide (H2S) donor against streptozotocin (STZ) -induced behavioral, oxidative abnormalities and its DN like symptoms in rats. METHODS: For the induction of DN single intraperitoneal administration of STZ (45 mg/kg) was given till third week. Behavioral parameters were measured on 1st, 7th, 21st and 42nd days and biochemical parameters were performed on 42nd day. All the drug treatments [NaHS (10 & 30 ?mol/kg i.p), DL-propargylglycine (10 mg/kg i.p), standard drug- Losartan (5 mg/kg p.o)] were given for 3 weeks staring from 21st day after the STZ injection. RESULTS: Three weeks treatment with sodium hydrosulphide (NaHS) (10 and 30 ?mol/kg i.p,) significantly attenuated the behavioral and biochemical abnormalities in STZ-treated animals. DL-propargylglycine (10 mg/kg i.p) pretreatment with sub-effective dose of NaHS (30 ?mol/kg i.p) significantly reversed the protective effect of NaHS. However, combination of both NaHS (30 ?mol/kg i.p) and standard drug losartan (5 mg/kg p.o) potentiated their effects as compared to their effect alone. CONCLUSION: The results of the present study suggest that H2S treatment showed significant improvement in behavioral and biochemical abnormalities induced by STZ administration. Thus H2S represents a target of treatment to prevent the progression of complications by DN. Twit Text FOAVip Combined effect of hydrogen sulphide donor and losartan in experimental diabetic nephropathy in rats ????J Diabetes Metab Disord http://www.kidney.de/pget.php?&tw=1&pmid=26221579 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26221579 #FOAvip English Wikipedia <ref>{{Cite pmid|26221579 }}</ref> Combined effect of hydrogen sulphide donor and losartan in experimental diabetic nephropathy in rats #MMPMID26221579 Kaur M ; Sachdeva S ; Bedi O ; Kaur T ; Kumar P J Diabetes Metab Disord 2015[]; 14 (ä): 63 PMID26221579 show ga BACKGROUND: Diabetic nephropathy (DN) is one of the complex complications of Diabetes Mellitus (DM). The present study has been designed to examine protective role of hydrogen Sulphide (H2S) donor against streptozotocin (STZ) -induced behavioral, oxidative abnormalities and its DN like symptoms in rats. METHODS: For the induction of DN single intraperitoneal administration of STZ (45 mg/kg) was given till third week. Behavioral parameters were measured on 1st, 7th, 21st and 42nd days and biochemical parameters were performed on 42nd day. All the drug treatments [NaHS (10 & 30 ?mol/kg i.p), DL-propargylglycine (10 mg/kg i.p), standard drug- Losartan (5 mg/kg p.o)] were given for 3 weeks staring from 21st day after the STZ injection. RESULTS: Three weeks treatment with sodium hydrosulphide (NaHS) (10 and 30 ?mol/kg i.p,) significantly attenuated the behavioral and biochemical abnormalities in STZ-treated animals. DL-propargylglycine (10 mg/kg i.p) pretreatment with sub-effective dose of NaHS (30 ?mol/kg i.p) significantly reversed the protective effect of NaHS. However, combination of both NaHS (30 ?mol/kg i.p) and standard drug losartan (5 mg/kg p.o) potentiated their effects as compared to their effect alone. CONCLUSION: The results of the present study suggest that H2S treatment showed significant improvement in behavioral and biochemical abnormalities induced by STZ administration. Thus H2S represents a target of treatment to prevent the progression of complications by DN. äCombined effect of hydrogen sulphide donor and losartan in experimenta(epmc).pdf DeepDyve Pubget Overpricing