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10.1073/pnas.1501662112 http://scihub22266oqcxt.onion/10.1073/pnas.1501662112 C4517270!4517270 !26150504     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26150504 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (29 ): E3883-92 Nephropedia Template TP {{tp|p=26150504 |t=2015. Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection |pdf=|usr=}}{{26150504 }} gab.com Text Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26150504 #FOAvip Molecular mechanisms for T-cell immune responses modulated by T cell-inhibitory molecules during tuberculosis (TB) infection remain unclear. Here, we show that active human TB infection up-regulates CD244 and CD244 signaling-associated molecules in CD8(+) T cells and that blockade of CD244 signaling enhances production of IFN-? and TNF-?. CD244 expression/signaling in TB correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1(1-72) or lncRNA-CD244] in the CD244(+)CD8(+) T-cell subpopulation. CD244 signaling drives lncRNA-CD244 expression via sustaining a permissive chromatin state in the lncRNA-CD244 locus. By recruiting polycomb protein enhancer of zeste homolog 2 (EZH2) to infg/tnfa promoters, lncRNA-CD244 mediates H3K27 trimethylation at infg/tnfa loci toward repressive chromatin states and inhibits IFN-?/TNF-? expression in CD8(+) T cells. Such inhibition can be reversed by knock down of lncRNA-CD244. Interestingly, adoptive transfer of lncRNA-CD244-depressed CD8(+) T cells to Mycobacterium tuberculosis (MTB)-infected mice reduced MTB infection and TB pathology compared with lncRNA-CD244-expressed controls. Thus, this work uncovers previously unidentified mechanisms in which T cell-inhibitory signaling and lncRNAs regulate T-cell responses and host defense against TB infection. Twit Text FOAVip Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26150504 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26150504 #FOAvip English Wikipedia <ref>{{Cite pmid|26150504 }}</ref> Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection #MMPMID26150504 Wang Y ; Zhong H ; Xie X ; Chen CY ; Huang D ; Shen L ; Zhang H ; Chen ZW ; Zeng G Proc Natl Acad Sci U S A 2015[Jul]; 112 (29 ): E3883-92 PMID26150504 show ga Molecular mechanisms for T-cell immune responses modulated by T cell-inhibitory molecules during tuberculosis (TB) infection remain unclear. Here, we show that active human TB infection up-regulates CD244 and CD244 signaling-associated molecules in CD8(+) T cells and that blockade of CD244 signaling enhances production of IFN-? and TNF-?. CD244 expression/signaling in TB correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1(1-72) or lncRNA-CD244] in the CD244(+)CD8(+) T-cell subpopulation. CD244 signaling drives lncRNA-CD244 expression via sustaining a permissive chromatin state in the lncRNA-CD244 locus. By recruiting polycomb protein enhancer of zeste homolog 2 (EZH2) to infg/tnfa promoters, lncRNA-CD244 mediates H3K27 trimethylation at infg/tnfa loci toward repressive chromatin states and inhibits IFN-?/TNF-? expression in CD8(+) T cells. Such inhibition can be reversed by knock down of lncRNA-CD244. Interestingly, adoptive transfer of lncRNA-CD244-depressed CD8(+) T cells to Mycobacterium tuberculosis (MTB)-infected mice reduced MTB infection and TB pathology compared with lncRNA-CD244-expressed controls. Thus, this work uncovers previously unidentified mechanisms in which T cell-inhibitory signaling and lncRNAs regulate T-cell responses and host defense against TB infection. |*Epigenesis, Genetic/drug effects [MESH] |*Immunity/drug effects/genetics [MESH] |*Signal Transduction/drug effects/genetics [MESH] |Adoptive Transfer [MESH] |Animals [MESH] |Antibodies, Monoclonal/pharmacology [MESH] |Antigens, CD [MESH] |Apoptosis/drug effects/genetics [MESH] |CD8-Positive T-Lymphocytes/cytology/drug effects/*immunology [MESH] |Chromatin/metabolism [MESH] |Computational Biology [MESH] |Conserved Sequence [MESH] |Enhancer of Zeste Homolog 2 Protein [MESH] |Evolution, Molecular [MESH] |Gene Knockdown Techniques [MESH] |Genome, Human [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Interferon-gamma/biosynthesis/genetics [MESH] |Intracellular Signaling Peptides and Proteins/metabolism [MESH] |Mice [MESH] |Models, Biological [MESH] |Polycomb Repressive Complex 2/metabolism [MESH] |Promoter Regions, Genetic/genetics [MESH] |Protein Binding/drug effects [MESH] |RNA, Long Noncoding/*genetics [MESH] |Receptors, Immunologic [MESH] |Signaling Lymphocytic Activation Molecule Associated Protein [MESH] |Signaling Lymphocytic Activation Molecule Family [MESH] |Transcription Factors/metabolism [MESH] |Tuberculosis/*immunology [MESH] |Tumor Necrosis Factor-alpha/biosynthesis/genetics [MESH]Long noncoding RNA derived from CD244 signaling epigenetically control(epmc).pdf DeepDyve Pubget Overpricing