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10.1073/pnas.1511814112 http://scihub22266oqcxt.onion/10.1073/pnas.1511814112 C4517227!4517227!26153421     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (29): E3836-44 Nephropedia Template TP {{tp|p=26153421|t=2015. Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision |pdf=|usr=}}{{26153421}} gab.com Text Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26153421 #FOAvip Developing effective antiangiogenesis strategies remains clinically challenging. Unlike physiological angiogenesis, pathological angiogenesis comprises of many microvessels that do not fully mature or develop functionally, because the cell fate decision about which endothelial cells become the tip and lead the following stalk cells is dysregulated. We devised a specific theoretical framework to decipher the cross-talk between two crucial players of the decision-making process of tip and stalk cell fate: VEGF and Notch-Delta-Jagged signaling. We find that high expression of Jagged, but not Delta, can destabilize the terminal differentiation into tip or stalk cells and give rise to a hybrid tip/stalk phenotype, a phenotype that can transform physiological into pathological angiogenesis. Our results offer insights into why tumor-stroma communication often implicates Jagged. Twit Text FOAVip Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26153421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26153421 #FOAvip English Wikipedia <ref>{{Cite pmid|26153421}}</ref> Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision #MMPMID26153421 Boareto M; Jolly MK; Ben-Jacob E; Onuchic JN Proc Natl Acad Sci U S A 2015[Jul]; 112 (29): E3836-44 PMID26153421show ga Developing effective antiangiogenesis strategies remains clinically challenging. Unlike physiological angiogenesis, pathological angiogenesis comprises of many microvessels that do not fully mature or develop functionally, because the cell fate decision about which endothelial cells become the tip and lead the following stalk cells is dysregulated. We devised a specific theoretical framework to decipher the cross-talk between two crucial players of the decision-making process of tip and stalk cell fate: VEGF and Notch-Delta-Jagged signaling. We find that high expression of Jagged, but not Delta, can destabilize the terminal differentiation into tip or stalk cells and give rise to a hybrid tip/stalk phenotype, a phenotype that can transform physiological into pathological angiogenesis. Our results offer insights into why tumor-stroma communication often implicates Jagged. äJagged mediates differences in normal and tumor angiogenesis by affect(epmc).pdf DeepDyve Pubget Overpricing