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10.1128/MMBR.00006-15 http://scihub22266oqcxt.onion/10.1128/MMBR.00006-15 C4517094!4517094!26223848     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microbiol+Mol+Biol+Rev 2015 ; 79 (3): 347-72 Nephropedia Template TP {{tp|p=26223848|t=2015. An Overview of Genome Organization and How We Got There: from FISH to Hi-C |pdf=|usr=}}{{26223848}} gab.com Text An Overview of Genome Organization and How We Got There: from FISH to Hi-C JO: Microbiol Mol Biol Rev http://www.kidney.de/pget.php?&tw=1&pmid=26223848 #FOAvip In humans, nearly two meters of genomic material must be folded to fit inside each micrometer-scale cell nucleus while remaining accessible for gene transcription, DNA replication, and DNA repair. This fact highlights the need for mechanisms governing genome organization during any activity and to maintain the physical organization of chromosomes at all times. Insight into the functions and three-dimensional structures of genomes comes mostly from the application of visual techniques such as fluorescence in situ hybridization (FISH) and molecular approaches including chromosome conformation capture (3C) technologies. Recent developments in both types of approaches now offer the possibility of exploring the folded state of an entire genome and maybe even the identification of how complex molecular machines govern its shape. In this review, we present key methodologies used to study genome organization and discuss what they reveal about chromosome conformation as it relates to transcription regulation across genomic scales in mammals. Twit Text FOAVip An Overview of Genome Organization and How We Got There: from FISH to Hi-C ????Microbiol Mol Biol Rev http://www.kidney.de/pget.php?&tw=1&pmid=26223848 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26223848 #FOAvip English Wikipedia <ref>{{Cite pmid|26223848}}</ref> An Overview of Genome Organization and How We Got There: from FISH to Hi-C #MMPMID26223848 Fraser J; Williamson I; Bickmore WA; Dostie J Microbiol Mol Biol Rev 2015[Sep]; 79 (3): 347-72 PMID26223848show ga In humans, nearly two meters of genomic material must be folded to fit inside each micrometer-scale cell nucleus while remaining accessible for gene transcription, DNA replication, and DNA repair. This fact highlights the need for mechanisms governing genome organization during any activity and to maintain the physical organization of chromosomes at all times. Insight into the functions and three-dimensional structures of genomes comes mostly from the application of visual techniques such as fluorescence in situ hybridization (FISH) and molecular approaches including chromosome conformation capture (3C) technologies. Recent developments in both types of approaches now offer the possibility of exploring the folded state of an entire genome and maybe even the identification of how complex molecular machines govern its shape. In this review, we present key methodologies used to study genome organization and discuss what they reveal about chromosome conformation as it relates to transcription regulation across genomic scales in mammals. äAn Overview of Genome Organization and How We Got There: from FISH to (epmc).pdf DeepDyve Pubget Overpricing