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Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl
Ester in Type 2 Diabetic Mice
#MMPMID26198246
Son DJ
; Hwang SY
; Kim MH
; Park UK
; Kim BS
Nutrients
2015[Jul]; 7
(7
): 5469-83
PMID26198246
show ga
Type 2 diabetes is a metabolic disorder caused by abnormal carbohydrate
metabolism, and closely associated with abnormal lipid metabolism and
hepato-renal dysfunction. This study investigated the anti-diabetic and
hepato-renal protective properties of ziyuglycoside I (ZG01) derivative on type 2
diabetes. ZG01 was isolated from roots of Sanguisorba officinalis and chemically
modified by deglycosylation and esterification to obtained ziyuglycoside II
methyl ester (ZG02-ME). Here, we showed that ZG02-ME has stronger anti-diabetic
activity than the original compound (ZG01) through decreasing blood glucose,
glycated hemoglobin (HbA1c), and insulin levels in a mouse model of type 2
diabetes (db/db mice). We further found that ZG02-ME treatment effectively
ameliorated serum insulin, leptin and C-peptide levels, which are key metabolic
hormones, in db/db mice. In addition, we showed that elevated basal blood lipid
levels were decreased by ZG02-ME treatment in db/db mice. Furthermore, treatment
of ZG02-ME significantly decreased serum AST, ALT, BUN, creatinine, and liver
lipid peroxidation in db/db mice. These results demonstrated that compared to
ZG01, chemically modified ZG02-ME possess improved anti-diabetic properties, and
has hepato-renal protective activities in type 2 diabetes.
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