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2015 ; 7
(7
): 5177-216
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A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular
Disease: Phenolic Compounds
#MMPMID26132993
Rangel-Huerta OD
; Pastor-Villaescusa B
; Aguilera CM
; Gil A
Nutrients
2015[Jun]; 7
(7
): 5177-216
PMID26132993
show ga
The prevalence of cardiovascular diseases (CVD) is rising and is the prime cause
of death in all developed countries. Bioactive compounds (BAC) can have a role in
CVD prevention and treatment. The aim of this work was to examine the scientific
evidence supporting phenolic BAC efficacy in CVD prevention and treatment by a
systematic review. Databases utilized were Medline, LILACS and EMBASE, and all
randomized controlled trials (RCTs) with prospective, parallel or crossover
designs in humans in which the effects of BAC were compared with that of
placebo/control were included. Vascular homeostasis, blood pressure, endothelial
function, oxidative stress and inflammatory biomarkers were considered as primary
outcomes. Cohort, ecological or case-control studies were not included. We
selected 72 articles and verified their quality based on the Scottish
Intercollegiate Guidelines Network, establishing diverse quality levels of
scientific evidence according to two features: the design and bias risk of a
study. Moreover, a grade of recommendation was included, depending on evidence
strength of antecedents. Evidence shows that certain polyphenols, such as
flavonols can be helpful in decreasing CVD risk factors. However, further
rigorous evidence is necessary to support the BAC effect on CVD prevention and
treatment.
|Biomarkers/blood
[MESH]
|Blood Pressure/drug effects
[MESH]
|Cardiovascular Diseases/drug therapy/*prevention & control
[MESH]