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10.1146/annurev-immunol-032712-095946 http://scihub22266oqcxt.onion/10.1146/annurev-immunol-032712-095946 C4516760!4516760!23330955     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Immunol 2013 ; 31 (ä): 675-704 Nephropedia Template TP {{tp|p=23330955|t=2013. Signalling by the phosphoinositide 3-kinase family in immune cells |pdf=|usr=}}{{23330955}} gab.com Text Signalling by the phosphoinositide 3-kinase family in immune cells JO: Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23330955 #FOAvip Phosphoinositide 3-kinases control many important aspects of immune cell development, differentiation and function. Mammals have eight PI3K catalytic subunits which are divided into 3 classes based on similarities in structure and function. Specific roles for the class I PI3Ks have been broadly investigated and are relatively well understood as is the function of their corresponding phosphatases. More recently, specific roles for the class II and class III PI3Ks have emerged. Through vertebrate evolution and in parallel with the evolution of adaptive immunity, there has been a dramatic increase not only in the genes for PI3K subunits but also in genes for phosphatases that act on 3-phopshoinositides and on 3-phosphoinositide binding proteins. Our understanding of the PI3Ks in immunity is guided by fundamental discoveries made in simpler model organisms as well as by appreciating new adaptions of this signalling module in mammals in general and immune cells in particular. Twit Text FOAVip Signalling by the phosphoinositide 3-kinase family in immune cells ????Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23330955 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23330955 #FOAvip English Wikipedia <ref>{{Cite pmid|23330955}}</ref> Signalling by the phosphoinositide 3-kinase family in immune cells #MMPMID23330955 Okkenhaug K Annu Rev Immunol 2013[]; 31 (ä): 675-704 PMID23330955show ga Phosphoinositide 3-kinases control many important aspects of immune cell development, differentiation and function. Mammals have eight PI3K catalytic subunits which are divided into 3 classes based on similarities in structure and function. Specific roles for the class I PI3Ks have been broadly investigated and are relatively well understood as is the function of their corresponding phosphatases. More recently, specific roles for the class II and class III PI3Ks have emerged. Through vertebrate evolution and in parallel with the evolution of adaptive immunity, there has been a dramatic increase not only in the genes for PI3K subunits but also in genes for phosphatases that act on 3-phopshoinositides and on 3-phosphoinositide binding proteins. Our understanding of the PI3Ks in immunity is guided by fundamental discoveries made in simpler model organisms as well as by appreciating new adaptions of this signalling module in mammals in general and immune cells in particular. äSignalling by the phosphoinositide 3-kinase family in immune cells (epmc).pdf DeepDyve Pubget Overpricing