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10.1016/j.toxlet.2015.06.012 http://scihub22266oqcxt.onion/10.1016/j.toxlet.2015.06.012 C4516600!4516600!26101797     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+Lett 2015 ; 237 (3): 219-27 Nephropedia Template TP {{tp|p=26101797|t=2015. An integrated view of cisplatin-induced nephrotoxicity and ototoxicity |pdf=|usr=}}{{26101797}} gab.com Text An integrated view of cisplatin-induced nephrotoxicity and ototoxicity JO: Toxicol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26101797 #FOAvip Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and ototoxic side-effects remain major clinical limitations. Recent studies have improved our understanding of the molecular mechanisms of cisplatin-induced nephrotoxicity and ototoxicity. While cisplatin binding to DNA is the major cytotoxic mechanism in proliferating (cancer) cells, nephrotoxicity and ototoxicity appear to result from toxic levels of reactive oxygen species and protein dysregulation within various cellular compartments. In this review, we discuss molecular mechanisms of cisplatin-induced nephrotoxicity and ototoxicity. We also discuss potential clinical strategies to prevent nephrotoxicity and ototoxicity and their current limitations. Twit Text FOAVip An integrated view of cisplatin-induced nephrotoxicity and ototoxicity ????Toxicol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26101797 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26101797 #FOAvip English Wikipedia <ref>{{Cite pmid|26101797}}</ref> An integrated view of cisplatin-induced nephrotoxicity and ototoxicity #MMPMID26101797 Karasawa T; Steyger PS Toxicol Lett 2015[Sep]; 237 (3): 219-27 PMID26101797show ga Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and ototoxic side-effects remain major clinical limitations. Recent studies have improved our understanding of the molecular mechanisms of cisplatin-induced nephrotoxicity and ototoxicity. While cisplatin binding to DNA is the major cytotoxic mechanism in proliferating (cancer) cells, nephrotoxicity and ototoxicity appear to result from toxic levels of reactive oxygen species and protein dysregulation within various cellular compartments. In this review, we discuss molecular mechanisms of cisplatin-induced nephrotoxicity and ototoxicity. We also discuss potential clinical strategies to prevent nephrotoxicity and ototoxicity and their current limitations. äAn integrated view of cisplatin-induced nephrotoxicity and ototoxicity(epmc).pdf DeepDyve Pubget Overpricing