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10.1038/srep12566 http://scihub22266oqcxt.onion/10.1038/srep12566 C4515826!4515826!26212640     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26212640|t=2015. Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity |pdf=|usr=}}{{26212640}} gab.com Text Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26212640 #FOAvip Cancer is widely recognized as a genetic disease in which somatic mutations are sequentially accumulated to drive tumor progression. Although genomic landscape studies are informative for individual cancer types, a comprehensive comparative study of tumorigenic mutations across cancer types based on integrative data sources is still a pressing need. We systematically analyzed ~106 non-synonymous mutations extracted from COSMIC, involving ~8000 genome-wide screened samples across 23 major human cancers at both the amino acid and gene levels. Our analysis identified cancer-specific heterogeneity that traditional nucleotide variation analysis alone usually overlooked. Particularly, the amino acid arginine (R) turns out to be the most favorable target of amino acid alteration in most cancer types studied (P?<?10?9, binomial test), reflecting its important role in cellular physiology. The tumor suppressor gene TP53 is mutated exclusively with the HYDIN, KRAS, and PTEN genes in large intestine, lung, and endometrial cancers respectively, indicating that TP53 takes part in different signaling pathways in different cancers. While some of our analyses corroborated previous observations, others indicated relevant candidates with high priority for further experimental validation. Our findings have many ramifications in understanding the etiology of cancer and the underlying molecular mechanisms in particular cancers. Twit Text FOAVip Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26212640 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26212640 #FOAvip English Wikipedia <ref>{{Cite pmid|26212640}}</ref> Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity #MMPMID26212640 Tan H; Bao J; Zhou X Sci Rep 2015[]; 5 (ä): ä PMID26212640show ga Cancer is widely recognized as a genetic disease in which somatic mutations are sequentially accumulated to drive tumor progression. Although genomic landscape studies are informative for individual cancer types, a comprehensive comparative study of tumorigenic mutations across cancer types based on integrative data sources is still a pressing need. We systematically analyzed ~106 non-synonymous mutations extracted from COSMIC, involving ~8000 genome-wide screened samples across 23 major human cancers at both the amino acid and gene levels. Our analysis identified cancer-specific heterogeneity that traditional nucleotide variation analysis alone usually overlooked. Particularly, the amino acid arginine (R) turns out to be the most favorable target of amino acid alteration in most cancer types studied (P? äGenome-wide mutational spectra analysis reveals significant cancer-spe(epmc).pdf DeepDyve Pubget Overpricing