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10.1016/j.smim.2015.03.004

http://scihub22266oqcxt.onion/10.1016/j.smim.2015.03.004
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C4515371!4515371!25857211
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suck abstract from ncbi


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pmid25857211      Semin+Immunol 2015 ; 27 (3): 200-15
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  • The Resolution Code of Acute Inflammation: Novel Pro-Resolving Lipid Mediators in Resolution #MMPMID25857211
  • Serhan CN; Chiang N; Dalli J
  • Semin Immunol 2015[May]; 27 (3): 200-15 PMID25857211show ga
  • Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro-resolving mediators (SPM) including lipoxins, resolvins, protectins and maresins that are each temporally produced by resolving-exudates with distinct actions for return to homeostasis. SPM evoke potent anti-inflammatory and novel pro-resolving mechanisms as well as enhance microbial clearance. While born in inflammation-resolution, SPM are conserved structures with functions discovered in microbial defense, pain, organ protection and tissue regeneration, wound healing, cancer, reproduction, and neurobiology-cognition. This review covers these SPM mechanisms and other new omega-3 PUFA pathways that open their path for functions in resolution physiology.
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