Role of Triglyceride-rich Lipoproteins in Renal Injury #MMPMID21659769
Ng KF; Aung HH; Rutledge JC
Contrib Nephrol 2011[]; 170 (ä): 165-71 PMID21659769show ga
Dyslipidemia is implicated as a risk factor for the development of atherosclerosis. Specifically triglyceride-rich lipoproteins (TGRL) and their lipolysis products are shown to be pro-inflammatory and pro-apoptosis in both in vivo and in vitro studies with endothelium. However the role of TGRL in the progression of kidney diseases is not clear. Epidemiology studies demonstrated a correlation between renal disease and blood lipids. Recent evidence suggests that the mechanism may involve cellular uptake of lipid and de novo lipogenesis. Further studies are needed to establish the relevance of these mechanistic studies in human pathophysiology.