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2015 ; 14
(1
): 34-41
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Association of High Sensitive CRP Level and COPD Assessment Test Scores with
Clinically Important Predictive Outcomes in Stable COPD Patients
#MMPMID26221150
Ghobadi H
; Fouladi N
; Beukaghazadeh K
; Ansarin K
Tanaffos
2015[]; 14
(1
): 34-41
PMID26221150
show ga
BACKGROUND: High sensitive CRP (hs-CRP) is used as a marker of systemic
inflammation in chronic obstructive pulmonary disease (COPD). However, we
hypothesize that the raised hs-CRP is not closely related to the multiple
consequences of COPD. This study was undertaken to investigate the association of
COPD assessment test (CAT) score with SpO2, FEV1, body mass index (BMI),
obstruction, dyspnea and exercise capacity (BODE) index and COPD exacerbation
rate and compare it with the association to serum hs-CRP level. MATERIALS AND
METHODS: Sixty patients with stable COPD referred to the pulmonology clinic of
Ardabil Imam Khomeini Hospital were included in this study. SpO2, 6-minute walk
distance (6MWD), body mass index, BODE index, and pulmonary function test as well
as exacerbation rate were determined in COPD patients. Then, the CAT
questionnaire was completed by patients. Serum level of hs-CRP was measured in
all patients and 15 controls. We statistically compared the relationships and
correlations among the variables. RESULTS: Hs-CRP level was significantly raised
in patients (P=0.005). In these patients, the correlation of hs-CRP level with
BODE index was significant (P=0.008). However, the correlation of hs-CRP with
SpO2 and FEV1 was not significant (P=0.47 and P=0.17, respectively). Also, the
correlation of CAT score with SpO2, FEV1, BODE index, and exacerbation rate in
the previous year was significant (P<0.001, P<0.001, P<0.001 and P=0.017,
respectively). CONCLUSION: SpO2, FEV1, BODE index and exacerbation rate are more
correlated with CAT scores than with the serum level of hs-CRP in stable COPD
patients. The findings of this study should be considered in management of stable
COPD patients.