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http://scihub22266oqcxt.onion/ C4515236!4515236!26221128     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Iran+J+Reprod+Med 2015 ; 13 (5): 291-6 Nephropedia Template TP {{tp|p=26221128|t=2015. Protective effects of ethyl pyruvate on sperm quality in cyclophosphamide treated mice |pdf=|usr=}}{{26221128}} gab.com Text Protective effects of ethyl pyruvate on sperm quality in cyclophosphamide treated mice JO: Iran J Reprod Med http://www.kidney.de/pget.php?&tw=1&pmid=26221128 #FOAvip Background:: One of the affecting factors in disturbance process of spermatogenesis is chemotherapeutic-induced oxidative stress resulted from cyclophosphamide (CP) treatment which leads to diminished sperm quality via interference in spermatogenesis process. Objective:: This study was conducted to investigate the effects of ethyl pyruvate (EP) in reducing the CP-induced side effects on reproductive system. Materials and Methods:: 24 mature male mice were randomly divided into 3 equal groups and were undergone therapy for 35 days. Control group received normal saline (0.1 ml/day, IP). CP group were injected CP (15 mg/kg/week, IP) and CP+EP group received EP (40 mg/kg/day, IP) as well as CP. In the end of the treatment period, the mice were euthanized by cervical dislocation. Then, the epididymis was incubated with CO2 in a human tubal fluid medium (1 ml) for half an hour in order to float sperm. Then, the number, motility, viability (eosin-nigrosin staining), DNA breakage (acridine orange staining), nucleus maturity, and sperm morphology (aniline blue staining) were analyzed. Results:: The average (15.87±1.28), motility (35.77±2.75), viability (40±3.03), nucleus maturity (36±2.79) and sperm morphology (61.75±0.85) were decreased significantly in CP group in comparison with control and EP groups, whereas EP caused significant increase of these parameters. Also, the percentage of DNA damage was increased significantly in CP group (41.75±3.75) in comparison with control (2±0.71) and EP groups (22.5±4.13). Conclusion:: The results of this study revealed ameliorating effects of EP on sperm quality of CP treated animals. Twit Text FOAVip Protective effects of ethyl pyruvate on sperm quality in cyclophosphamide treated mice ????Iran J Reprod Med http://www.kidney.de/pget.php?&tw=1&pmid=26221128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26221128 #FOAvip English Wikipedia <ref>{{Cite pmid|26221128}}</ref> Protective effects of ethyl pyruvate on sperm quality in cyclophosphamide treated mice #MMPMID26221128 Bakhtiary Z; Shahrooz R; Ahmadi A; Zarei L Iran J Reprod Med 2015[May]; 13 (5): 291-6 PMID26221128show ga Background:: One of the affecting factors in disturbance process of spermatogenesis is chemotherapeutic-induced oxidative stress resulted from cyclophosphamide (CP) treatment which leads to diminished sperm quality via interference in spermatogenesis process. Objective:: This study was conducted to investigate the effects of ethyl pyruvate (EP) in reducing the CP-induced side effects on reproductive system. Materials and Methods:: 24 mature male mice were randomly divided into 3 equal groups and were undergone therapy for 35 days. Control group received normal saline (0.1 ml/day, IP). CP group were injected CP (15 mg/kg/week, IP) and CP+EP group received EP (40 mg/kg/day, IP) as well as CP. In the end of the treatment period, the mice were euthanized by cervical dislocation. Then, the epididymis was incubated with CO2 in a human tubal fluid medium (1 ml) for half an hour in order to float sperm. Then, the number, motility, viability (eosin-nigrosin staining), DNA breakage (acridine orange staining), nucleus maturity, and sperm morphology (aniline blue staining) were analyzed. Results:: The average (15.87±1.28), motility (35.77±2.75), viability (40±3.03), nucleus maturity (36±2.79) and sperm morphology (61.75±0.85) were decreased significantly in CP group in comparison with control and EP groups, whereas EP caused significant increase of these parameters. Also, the percentage of DNA damage was increased significantly in CP group (41.75±3.75) in comparison with control (2±0.71) and EP groups (22.5±4.13). Conclusion:: The results of this study revealed ameliorating effects of EP on sperm quality of CP treated animals. äProtective effects of ethyl pyruvate on sperm quality in cyclophospham(epmc).pdf DeepDyve Pubget Overpricing