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10.1002/hep.27857 http://scihub22266oqcxt.onion/10.1002/hep.27857 C4515147!4515147 !25891479     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25891479 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hepatology 2015 ; 62 (2 ): 591-9 Nephropedia Template TP {{tp|p=25891479 |t=2015. Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury |pdf=|usr=}}{{25891479 }} gab.com Text Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury JO: Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=25891479 #FOAvip Acute kidney injury in the context of acetaminophen (APAP; paracetamol)-induced liver injury is an important predictor of the requirement for urgent liver transplantation (LT) to avoid death. However, the prognostic biomarker used to report kidney dysfunction (serum creatinine concentration) has suboptimal sensitivity and specificity. Kidney injury molecule 1 (KIM-1) can be quantified in plasma as a sensitive and specific biomarker of kidney injury in both clinical and preclinical studies. Therefore, plasma KIM-1 has potential as a sensitive prognostic biomarker of patient outcome post-APAP overdose. In a cohort of APAP overdose patients (N?=?74) with and without established liver injury, we quantified plasma KIM-1 by immunoassay on the first day of admission to a LT unit and assessed its diagnostic performance to predict outcome compared with serum creatinine concentration. Day 1 plasma KIM-1 was significantly elevated in patients that died or required LT, compared to spontaneous survivors (1,182?±?251 vs. 214?±?45 pg/mL; P?<?0.005). Receiver operator characteristic analysis demonstrated the superiority of KIM-1 (area under the curve [AUC]: 0.87; 95% confidence interval [CI]: 0.78-0.95; 0.56 sensitivity at 0.95 specificity), compared with serum creatinine (AUC, 0.76; 95% CI: 0.64-0.87; 0.08 sensitivity at 0.95 specificity) and other current prognostic indicators, when measured on the first day of enrollment into the study. Furthermore, KIM-1 was found to be a statistically significant independent predictor of outcome at the 5% level (P?<?0.0386) in a multivariable logistic regression model that considered all measured factors (pseudo-R^2?=?0.895). CONCLUSION: Early measurement of plasma KIM-1 represents a more sensitive predictor of patient outcome than serum creatinine concentration post-APAP overdose. With further development, plasma KIM-1 could significantly improve prognostic stratification. Twit Text FOAVip Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury ????Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=25891479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25891479 #FOAvip English Wikipedia <ref>{{Cite pmid|25891479 }}</ref> Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury #MMPMID25891479 Antoine DJ ; Sabbisetti VS ; Francis B ; Jorgensen AL ; Craig DG ; Simpson KJ ; Bonventre JV ; Park BK ; Dear JW Hepatology 2015[Aug]; 62 (2 ): 591-9 PMID25891479 show ga Acute kidney injury in the context of acetaminophen (APAP; paracetamol)-induced liver injury is an important predictor of the requirement for urgent liver transplantation (LT) to avoid death. However, the prognostic biomarker used to report kidney dysfunction (serum creatinine concentration) has suboptimal sensitivity and specificity. Kidney injury molecule 1 (KIM-1) can be quantified in plasma as a sensitive and specific biomarker of kidney injury in both clinical and preclinical studies. Therefore, plasma KIM-1 has potential as a sensitive prognostic biomarker of patient outcome post-APAP overdose. In a cohort of APAP overdose patients (N?=?74) with and without established liver injury, we quantified plasma KIM-1 by immunoassay on the first day of admission to a LT unit and assessed its diagnostic performance to predict outcome compared with serum creatinine concentration. Day 1 plasma KIM-1 was significantly elevated in patients that died or required LT, compared to spontaneous survivors (1,182?±?251 vs. 214?±?45 pg/mL; P? |Acetaminophen/administration & dosage/*adverse effects [MESH] |Adult [MESH] |Area Under Curve [MESH] |Biomarkers/blood [MESH] |Chemical and Drug Induced Liver Injury/*blood/*mortality/surgery [MESH] |Cohort Studies [MESH] |Creatinine/blood [MESH] |Female [MESH] |Graft Survival [MESH] |Hepatitis A Virus Cellular Receptor 1 [MESH] |Humans [MESH] |Liver Transplantation/methods/*mortality [MESH] |Logistic Models [MESH] |Male [MESH] |Membrane Glycoproteins/*metabolism [MESH] |Middle Aged [MESH] |Predictive Value of Tests [MESH] |Prognosis [MESH] |Prospective Studies [MESH] |ROC Curve [MESH] |Receptors, Virus/*metabolism [MESH] |Risk Assessment [MESH] |Severity of Illness Index [MESH]Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outco(epmc).pdf DeepDyve Pubget Overpricing