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10.1038/ncomms7768 http://scihub22266oqcxt.onion/10.1038/ncomms7768 C4515032!4515032 !25866135     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25866135 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2015 ; 6 (ä): 6768 Nephropedia Template TP {{tp|p=25866135 |t=2015. Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain |pdf=|usr=}}{{25866135 }} gab.com Text Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25866135 #FOAvip The brain has a limited capacity to self-protect against protein aggregate-associated pathology, and mounting evidence supports a role for phagocytic glia in this process. We have established a Drosophila model to investigate the role of phagocytic glia in clearance of neuronal mutant huntingtin (Htt) aggregates associated with Huntington disease. We find that glia regulate steady-state numbers of Htt aggregates expressed in neurons through a clearance mechanism that requires the glial scavenger receptor Draper and downstream phagocytic engulfment machinery. Remarkably, some of these engulfed neuronal Htt aggregates effect prion-like conversion of soluble, wild-type Htt in the glial cytoplasm. We provide genetic evidence that this conversion depends strictly on the Draper signalling pathway, unveiling a previously unanticipated role for phagocytosis in transfer of pathogenic protein aggregates in an intact brain. These results suggest a potential mechanism by which phagocytic glia contribute to both protein aggregate-related neuroprotection and pathogenesis in neurodegenerative disease. Twit Text FOAVip Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25866135 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25866135 #FOAvip English Wikipedia <ref>{{Cite pmid|25866135 }}</ref> Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain #MMPMID25866135 Pearce MMP ; Spartz EJ ; Hong W ; Luo L ; Kopito RR Nat Commun 2015[Apr]; 6 (ä): 6768 PMID25866135 show ga The brain has a limited capacity to self-protect against protein aggregate-associated pathology, and mounting evidence supports a role for phagocytic glia in this process. We have established a Drosophila model to investigate the role of phagocytic glia in clearance of neuronal mutant huntingtin (Htt) aggregates associated with Huntington disease. We find that glia regulate steady-state numbers of Htt aggregates expressed in neurons through a clearance mechanism that requires the glial scavenger receptor Draper and downstream phagocytic engulfment machinery. Remarkably, some of these engulfed neuronal Htt aggregates effect prion-like conversion of soluble, wild-type Htt in the glial cytoplasm. We provide genetic evidence that this conversion depends strictly on the Draper signalling pathway, unveiling a previously unanticipated role for phagocytosis in transfer of pathogenic protein aggregates in an intact brain. These results suggest a potential mechanism by which phagocytic glia contribute to both protein aggregate-related neuroprotection and pathogenesis in neurodegenerative disease. |Animals [MESH] |Bacterial Proteins/genetics/metabolism [MESH] |Brain/metabolism/pathology [MESH] |Disease Models, Animal [MESH] |Disease Progression [MESH] |Drosophila Proteins/*genetics/metabolism [MESH] |Drosophila melanogaster/*genetics/metabolism [MESH] |Gene Expression Regulation [MESH] |Genes, Reporter [MESH] |Humans [MESH] |Huntingtin Protein [MESH] |Huntington Disease/genetics/metabolism/*pathology [MESH] |Luminescent Proteins/genetics/metabolism [MESH] |Membrane Proteins/*genetics/metabolism [MESH] |Microtubule-Associated Proteins/*genetics/metabolism [MESH] |Molecular Mimicry [MESH] |Mutation [MESH] |Neuroglia/chemistry/*metabolism/pathology [MESH] |Neurons/chemistry/*metabolism/pathology [MESH] |Phagocytosis [MESH] |Prions/chemistry/metabolism [MESH] |Protein Aggregates [MESH] |Protein Aggregation, Pathological/*genetics/metabolism [MESH] |Red Fluorescent Protein [MESH]Prion-like transmission of neuronal huntingtin aggregates to phagocyti(epmc).pdf DeepDyve Pubget Overpricing