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10.1371/journal.pone.0133280 http://scihub22266oqcxt.onion/10.1371/journal.pone.0133280 C4514710!4514710!26208222     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26208222&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (7): ä Nephropedia Template TP {{tp|p=26208222|t=2015. c-Myb Binding Sites in Haematopoietic Chromatin Landscapes |pdf=|usr=}}{{26208222}} gab.com Text c-Myb Binding Sites in Haematopoietic Chromatin Landscapes JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26208222 #FOAvip Strict control of tissue-specific gene expression plays a pivotal role during lineage commitment. The transcription factor c-Myb has an essential role in adult haematopoiesis and functions as an oncogene when rearranged in human cancers. Here we have exploited digital genomic footprinting analysis to obtain a global picture of c-Myb occupancy in the genome of six different haematopoietic cell-types. We have biologically validated several c-Myb footprints using c-Myb knockdown data, reporter assays and DamID analysis. We show that our predicted conserved c-Myb footprints are highly dependent on the haematopoietic cell type, but that there is a group of gene targets common to all cell-types analysed. Furthermore, we find that c-Myb footprints co-localise with active histone mark H3K4me3 and are significantly enriched at exons. We analysed co-localisation of c-Myb footprints with 104 chromatin regulatory factors in K562 cells, and identified nine proteins that are enriched together with c-Myb footprints on genes positively regulated by c-Myb and one protein enriched on negatively regulated genes. Our data suggest that c-Myb is a transcription factor with multifaceted target regulation depending on cell type. Twit Text FOAVip c-Myb Binding Sites in Haematopoietic Chromatin Landscapes ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26208222 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26208222 #FOAvip English Wikipedia <ref>{{Cite pmid|26208222}}</ref> c-Myb Binding Sites in Haematopoietic Chromatin Landscapes #MMPMID26208222 Bengtsen M; Klepper K; Gundersen S; Cuervo I; Drabløs F; Hovig E; Sandve GK; Gabrielsen OS; Eskeland R PLoS One 2015[]; 10 (7): ä PMID26208222show ga Strict control of tissue-specific gene expression plays a pivotal role during lineage commitment. The transcription factor c-Myb has an essential role in adult haematopoiesis and functions as an oncogene when rearranged in human cancers. Here we have exploited digital genomic footprinting analysis to obtain a global picture of c-Myb occupancy in the genome of six different haematopoietic cell-types. We have biologically validated several c-Myb footprints using c-Myb knockdown data, reporter assays and DamID analysis. We show that our predicted conserved c-Myb footprints are highly dependent on the haematopoietic cell type, but that there is a group of gene targets common to all cell-types analysed. Furthermore, we find that c-Myb footprints co-localise with active histone mark H3K4me3 and are significantly enriched at exons. We analysed co-localisation of c-Myb footprints with 104 chromatin regulatory factors in K562 cells, and identified nine proteins that are enriched together with c-Myb footprints on genes positively regulated by c-Myb and one protein enriched on negatively regulated genes. Our data suggest that c-Myb is a transcription factor with multifaceted target regulation depending on cell type. äc-Myb Binding Sites in Haematopoietic Chromatin Landscapes (epmc).pdf DeepDyve Pubget Overpricing