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Coupled cell networks are target cells of inflammation, which can spread between
different body organs and develop into systemic chronic inflammation
#MMPMID26213498
Hansson E
; Skiöldebrand E
J Inflamm (Lond)
2015[]; 12
(?): 44
PMID26213498
show ga
Several organs in the body comprise cells coupled into networks. These cells have
in common that they are excitable but do not express action potentials.
Furthermore, they are equipped with Ca(2+) signaling systems, which can be
intercellular and/or extracellular. The transport of small molecules between the
cells occurs through gap junctions comprising connexin 43. Examples of cells
coupled into networks include astrocytes, keratinocytes, chondrocytes, synovial
fibroblasts, osteoblasts, connective tissue cells, cardiac and corneal
fibroblasts, myofibroblasts, hepatocytes, and different types of glandular cells.
These cells are targets for inflammation, which can be initiated after injury or
in disease. If the inflammation reaches the CNS, it develops into
neuroinflammation and can be of importance in the development of systemic chronic
inflammation, which can manifest as pain and result in changes in the expression
and structure of cellular components. Biochemical parameters of importance for
cellular functions are described in this review.
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