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Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Genome+Biol 2015 ; 16 (1): ä Nephropedia Template TP
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Chromatin segmentation based on a probabilistic model for read counts explains a large portion of the epigenome #MMPMID26206277
Mammana A; Chung HR
Genome Biol 2015[]; 16 (1): ä PMID26206277show ga
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is an increasingly common experimental approach to generate genome-wide maps of histone modifications and to dissect the complexity of the epigenome. Here, we propose EpiCSeg: a novel algorithm that combines several histone modification maps for the segmentation and characterization of cell-type specific epigenomic landscapes. By using an accurate probabilistic model for the read counts, EpiCSeg provides a useful annotation for a considerably larger portion of the genome, shows a stronger association with validation data, and yields more consistent predictions across replicate experiments when compared to existing methods.The software is available at http://github.com/lamortenera/epicsegElectronic supplementary material: The online version of this article (doi:10.1186/s13059-015-0708-z) contains supplementary material, which is available to authorized users.