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10.1126/science.1258366 http://scihub22266oqcxt.onion/10.1126/science.1258366 C4513950!4513950!25908823     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 348 (6233): 453-7 Nephropedia Template TP {{tp|p=25908823|t=2015. SARM1 activation triggers axon degeneration locally via NAD+ destruction |pdf=|usr=}}{{25908823}} gab.com Text SARM1 activation triggers axon degeneration locally via NAD+ destruction JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25908823 #FOAvip Axon degeneration is an intrinsic self-destruction program that underlies axon loss during injury and disease. Sterile alpha and TIR motif containing 1 (SARM1) protein is an essential mediator of axon degeneration. We report that SARM1 initiates a local destruction program involving rapid breakdown of NAD+ after injury. We used an engineered protease-sensitized SARM1 to demonstrate that SARM1 activity is required after axon injury to induce axon degeneration. Dimerization of the Toll-Interleukin Receptor (TIR) domain of SARM1 alone was sufficient to induce locally-mediated axon degeneration. Formation of the SARM1 TIR dimer triggered rapid breakdown of NAD+, whereas SARM1-induced axon destruction could be counteracted by increased NAD+ synthesis. SARM1-induced depletion of NAD+ may explain the potent axon protection in Wallerian Degeneration slow (Wlds) mutant mice. Twit Text FOAVip SARM1 activation triggers axon degeneration locally via NAD+ destruction ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25908823 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25908823 #FOAvip English Wikipedia <ref>{{Cite pmid|25908823}}</ref> SARM1 activation triggers axon degeneration locally via NAD+ destruction #MMPMID25908823 Gerdts J; Brace E; Sasaki Y; DiAntonio A; Milbrandt J Science 2015[Apr]; 348 (6233): 453-7 PMID25908823show ga Axon degeneration is an intrinsic self-destruction program that underlies axon loss during injury and disease. Sterile alpha and TIR motif containing 1 (SARM1) protein is an essential mediator of axon degeneration. We report that SARM1 initiates a local destruction program involving rapid breakdown of NAD+ after injury. We used an engineered protease-sensitized SARM1 to demonstrate that SARM1 activity is required after axon injury to induce axon degeneration. Dimerization of the Toll-Interleukin Receptor (TIR) domain of SARM1 alone was sufficient to induce locally-mediated axon degeneration. Formation of the SARM1 TIR dimer triggered rapid breakdown of NAD+, whereas SARM1-induced axon destruction could be counteracted by increased NAD+ synthesis. SARM1-induced depletion of NAD+ may explain the potent axon protection in Wallerian Degeneration slow (Wlds) mutant mice. äSARM1 activation triggers axon degeneration locally via NAD+ destructi(epmc).pdf DeepDyve Pubget Overpricing