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2015 ; 10
(2
): 619-624
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English Wikipedia
BTG1 potentiates apoptosis and suppresses proliferation in renal cell carcinoma
by interacting with PRMT1
#MMPMID26622543
Liu C
; Tao T
; Xu B
; Lu K
; Zhang L
; Jiang L
; Chen S
; Liu D
; Zhang X
; Cao N
; Chen M
Oncol Lett
2015[Aug]; 10
(2
): 619-624
PMID26622543
show ga
B-cell translocation gene 1 (BTG1) is a member of the BTG/transducer of Erb
family. BTG1 regulates cell cycle progression, inhibits proliferation, promotes
apoptosis and stimulates cellular differentiation in multiple cell types.
However, the functions of BTG1 in renal cell carcinoma (RCC) remain unclear.
Therefore, the present study investigated the role of BTG1 in RCC tissue samples
and 786-O RCC cells. RCC tissues and cells exhibited significantly weaker BTG1
protein and mRNA expression compared with para-carcinoma control tissues
(P<0.05). Upregulated BTG1 expression induced significant G0/G1 cell cycle
arrest, apoptosis and inhibition of cell proliferation in 786-O cells (P<0.05).
Furthermore, BTG1 interacted with protein arginine N-methyltransferase 1 (PRMT1),
and blocking the action of PRMT1 in 786-O cells resulted in inhibition of BTG1
function. These findings indicate that BTG1 may inhibit cell growth and promote
apoptosis by interacting with PRMT1 in RCC; the identification of this mechanism
may aid in the production of novel therapies for RCC.