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10.1038/nrm3896

http://scihub22266oqcxt.onion/10.1038/nrm3896
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C4513363!4513363!25355505
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suck abstract from ncbi


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pmid25355505      Nat+Rev+Mol+Cell+Biol 2014 ; 15 (12): 802-12
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  • Mechanotransduction and extracellular matrix homeostasis #MMPMID25355505
  • Humphrey JD; Dufresne ER; Schwartz MA
  • Nat Rev Mol Cell Biol 2014[Dec]; 15 (12): 802-12 PMID25355505show ga
  • Soft connective tissues at steady state are yet dynamic; resident cells continually read environmental cues and respond to promote homeostasis, including maintenance of the mechanical properties of the extracellular matrix that are fundamental to cellular and tissue health. The mechanosensing process involves assessment of the mechanics of the matrix by the cells through integrins and the actomyosin cytoskeleton, and is followed by a mechano-regulation process that includes the deposition, rearrangement, or removal of matrix to maintain overall form and function. Progress toward understanding the molecular, cellular, and tissue scale effects that promote mechanical homeostasis has helped identify key questions for future research.
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