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10.1016/j.bbrc.2012.06.050

http://scihub22266oqcxt.onion/10.1016/j.bbrc.2012.06.050
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C4512951!4512951!22713465
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suck abstract from ncbi


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pmid22713465      Biochem+Biophys+Res+Commun 2012 ; 423 (3): 613-9
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  • Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis #MMPMID22713465
  • Yao Y; Fan Y; Wu J; Wan H; Wang J; Lam S; Lam WL; Girard L; Gazdar AF; Wu Z; Zhou Q
  • Biochem Biophys Res Commun 2012[Jul]; 423 (3): 613-9 PMID22713465show ga
  • To identify a panel of tumor associated autoantibodies which can potentially be used as biomarkers for the early diagnosis of non-small cell lung cancer (NSCLC). Thirty-five unique and in-frame expressed phage proteins were isolated. Based on the gene expression profiling, four proteins were selected for further study. Both receiver operating characteristic curve analysis and leave-one-out method revealed that combined measurements of four antibodies produced have better predictive accuracies than any single marker alone. Leave-one-out validation also showed significant relevance with all stages of NSCLC patients. The panel of autoantibodies has a high potential for detecting early stage NSCLC.
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