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10.1097/PAS.0b013e318186235b

http://scihub22266oqcxt.onion/10.1097/PAS.0b013e318186235b
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C4512670!4512670!18987548
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suck abstract from ncbi


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pmid18987548      Am+J+Surg+Pathol 2009 ; 33 (2): 211-7
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  • Embryonal Tumors With Abundant Neuropil and True Rosettes: A Distinctive CNS Primitive Neuroectodermal Tumor #MMPMID18987548
  • Gessi M; Giangaspero F; Lauriola L; Gardiman M; Scheithauer BW; Halliday W; Hawkins C; Rosenblum MK; Burger PC; Eberhart CG
  • Am J Surg Pathol 2009[Feb]; 33 (2): 211-7 PMID18987548show ga
  • Embryonal neoplasms of the central nervous system (CNS) generally arise in the early years of life and behave in a clinically aggressive manner, but vary somewhat in their microscopic appearance. Several groups have reported examples of an embryonal tumor with combined histologic features of ependymoblastoma and neuroblastoma, a lesion referred to as ?embryonal tumor with abundant neuropil and true rosettes? (ETANTR). Herein, we present 22 new cases, and additional clinical follow-up on our 7 initially reported cases, to better define the histologic features and clinical behavior of this distinctive neoplasm. It affects infants and arises most often in cerebral cortex, the cerebellum and brainstem being less frequent sites. Unlike other embryonal tumors of the CNS, girls are more commonly affected than boys. On neuroimaging, the tumors appear as large, demarcated, solid masses featuring patchy or no contrast enhancement. Five of our cases (18%) were at least partly cystic. Distinctive microscopic features include a prominent background of mature neuropil punctuated by true rosettes formed of pseudo-stratified embryonal cells circumferentially disposed about a central lumen (true rosettes). Of the 25 cases with available follow-up, 19 patients have died, their median survival being 9 months. Performed on 2 cases, cytogenetic analysis revealed extra copies of chromosome 2 in both. We believe that the ETANTR represents a histologically distinctive form of CNS embryonal tumor.
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