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10.4049/jimmunol.1401805 http://scihub22266oqcxt.onion/10.4049/jimmunol.1401805 C4512253!4512253!25381357     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 193 (10): 4761-8 Nephropedia Template TP {{tp|p=25381357|t=2014. Role and regulation of CD1d in normal and pathological B cells |pdf=|usr=}}{{25381357}} gab.com Text Role and regulation of CD1d in normal and pathological B cells JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25381357 #FOAvip CD1d is a non-polymorphic, MHC class I-like molecule, which presents phosphoand glycosphingo-lipid antigens to a subset of CD1d-restricted T cells called invariant NKT (iNKT) cells. This CD1d-iNKT cell axis regulates nearly all aspects of both the innate and adaptive immune response. Expression of CD1d on B cells is suggestive of the ability of these cells to present antigen to and form cognate interactions with iNKT cells. Herein we summarise key evidence regarding the role and regulation of CD1d in normal B cells and in humoral immunity. We then extend the discussion to B cell disorders, with emphasis on autoimmune disease, viral infection and neoplastic transformation of B lineage cells, where CD1d expression can be altered as a mechanism of immune evasion, and can have both diagnostic and prognostic importance. Finally we highlight current and future therapeutic strategies that aim to target the CD1d-iNKT axis in B cells. Twit Text FOAVip Role and regulation of CD1d in normal and pathological B cells ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25381357 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25381357 #FOAvip English Wikipedia <ref>{{Cite pmid|25381357}}</ref> Role and regulation of CD1d in normal and pathological B cells #MMPMID25381357 Chaudhry MS; Karadimitris A J Immunol 2014[Nov]; 193 (10): 4761-8 PMID25381357show ga CD1d is a non-polymorphic, MHC class I-like molecule, which presents phosphoand glycosphingo-lipid antigens to a subset of CD1d-restricted T cells called invariant NKT (iNKT) cells. This CD1d-iNKT cell axis regulates nearly all aspects of both the innate and adaptive immune response. Expression of CD1d on B cells is suggestive of the ability of these cells to present antigen to and form cognate interactions with iNKT cells. Herein we summarise key evidence regarding the role and regulation of CD1d in normal B cells and in humoral immunity. We then extend the discussion to B cell disorders, with emphasis on autoimmune disease, viral infection and neoplastic transformation of B lineage cells, where CD1d expression can be altered as a mechanism of immune evasion, and can have both diagnostic and prognostic importance. Finally we highlight current and future therapeutic strategies that aim to target the CD1d-iNKT axis in B cells. äRole and regulation of CD1d in normal and pathological B cells (epmc).pdf DeepDyve Pubget Overpricing