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2015 ; 10
(7
): e0133675
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Accuracy of Urinary Neutrophil Gelatinase-Associated Lipocalin in Quantifying
Acute Kidney Injury after Partial Nephrectomy in Patients with Normal
Contralateral Kidney
#MMPMID26200468
Koo KC
; Hong JH
; Lee HS
; Jeh SU
; Choi YD
; Rha KH
; Ham WS
PLoS One
2015[]; 10
(7
): e0133675
PMID26200468
show ga
BACKGROUND: To evaluate the efficacy of urinary neutrophil gelatinase-associated
lipocalin (uNGAL) for predicting the degree of acute kidney injury (AKI) in
patients following partial nephrectomy (PN). METHODS: This prospective study
included 176 patients who underwent open or laparoscopic PN for solid renal
tumors between June 2013 and May 2014. Urine samples were collected
preoperatively and at 3, 24, and 48 h after renal pedicle clamp removal. Changes
in uNGAL levels were analyzed for all patients and between subgroups that were
dichotomized based on preoperative eGFR values of <60 and ?60 mL/min/1.73m2, open
and laparoscopic surgery, and according to the onset of AKI. Linear mixed models
were used to investigate preoperative and perioperative features associated with
postoperative uNGAL and eGFR changes at 6 months postoperatively. RESULTS: Among
146 patients included in the final analysis, 10 (6.8%) patients had preoperative
eGFR <60 mL/min/1.73m2. In the overall group, uNGAL levels increased following
PN. However, all subgroups demonstrated comparable changes in uNGAL levels over
time. Multivariate analyses failed to reveal any correctable clinical features
associated with postoperative uNGAL changes, whereas preoperative serum
creatinine levels and the onset of AKI correlated with eGFR at 6 months
postoperatively. CONCLUSIONS: uNGAL levels may increase following PN. However, it
does not appear to be a useful marker for quantifying the degree of AKI or
predicting postoperative renal function in patients with normal contralateral
kidney and relatively good preoperative renal function. Further analysis is
necessary to assess the usefulness of uNGAL in patients with poor preoperative
renal function.