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10.1016/j.cell.2011.10.033

http://scihub22266oqcxt.onion/10.1016/j.cell.2011.10.033
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C4511103!4511103!22078876
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suck abstract from ncbi


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pmid22078876      Cell 2011 ; 147 (4): 742-58
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  • Programmed Cell Death in Animal Development and Disease #MMPMID22078876
  • Fuchs Y; Steller H
  • Cell 2011[Nov]; 147 (4): 742-58 PMID22078876show ga
  • Programmed Cell Death (PCD) plays a fundamental role in animal development and tissue homeostasis. Abnormal regulation of this process is associated with a wide variety of human diseases, including immunological and developmental disorders, neuro-degeneration, and cancer. Here, we provide a brief historical overview of the field and reflect on myriad functions carried out by PCD during development and explore how PCD is regulated. We also focus on the function and regulation of apoptotic proteins, including caspases, the key executioners of apoptosis, highlighting the non-lethal functions of these proteins in diverse developmental processes including cell differentiation and tissue remodeling. Finally, we explore a growing body of work about the connections between apoptosis, stem cells and cancer, focusing on how apoptotic cells release a variety of signals to communicate with their cellular environment, including factors that promote cell division, tissue regeneration, and wound healing.
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