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10.1038/ncomms8398 http://scihub22266oqcxt.onion/10.1038/ncomms8398 C4510695!4510695!26154507     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26154507|t=2015. Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance |pdf=|usr=}}{{26154507}} gab.com Text Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26154507 #FOAvip The generation of induced pluripotent stem (iPS) cells holds great promise in regenerative medicine. The use of the transcription factors Oct4, Sox2, Klf4 and c-Myc for reprogramming is extensively documented, but comparatively little is known about soluble molecules promoting reprogramming. Here we identify the secreted cue Netrin-1 and its receptor DCC, described for their respective survival/death functions in normal and oncogenic contexts, as reprogramming modulators. In various somatic cells, we found that reprogramming is accompanied by a transient transcriptional repression of Netrin-1 mediated by an Mbd3/Mta1/Chd4-containing NuRD complex. Mechanistically, Netrin-1 imbalance induces apoptosis mediated by the receptor DCC in a p53-independent manner. Correction of the Netrin-1/DCC equilibrium constrains apoptosis and improves reprogramming efficiency. Our work also sheds light on Netrin-1's function in protecting embryonic stem cells from apoptosis mediated by its receptor UNC5b, and shows that the treatment with recombinant Netrin-1 improves the generation of mouse and human iPS cells. Twit Text FOAVip Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26154507 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26154507 #FOAvip English Wikipedia <ref>{{Cite pmid|26154507}}</ref> Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance #MMPMID26154507 Ozmadenci D; Féraud O; Markossian S; Kress E; Ducarouge B; Gibert B; Ge J; Durand I; Gadot N; Plateroti M; Bennaceur-Griscelli A; Scoazec JY; Gil J; Deng H; Bernet A; Mehlen P; Lavial F Nat Commun 2015[]; 6 (ä): ä PMID26154507show ga The generation of induced pluripotent stem (iPS) cells holds great promise in regenerative medicine. The use of the transcription factors Oct4, Sox2, Klf4 and c-Myc for reprogramming is extensively documented, but comparatively little is known about soluble molecules promoting reprogramming. Here we identify the secreted cue Netrin-1 and its receptor DCC, described for their respective survival/death functions in normal and oncogenic contexts, as reprogramming modulators. In various somatic cells, we found that reprogramming is accompanied by a transient transcriptional repression of Netrin-1 mediated by an Mbd3/Mta1/Chd4-containing NuRD complex. Mechanistically, Netrin-1 imbalance induces apoptosis mediated by the receptor DCC in a p53-independent manner. Correction of the Netrin-1/DCC equilibrium constrains apoptosis and improves reprogramming efficiency. Our work also sheds light on Netrin-1's function in protecting embryonic stem cells from apoptosis mediated by its receptor UNC5b, and shows that the treatment with recombinant Netrin-1 improves the generation of mouse and human iPS cells. äNetrin-1 regulates somatic cell reprogramming and pluripotency mainten(epmc).pdf DeepDyve Pubget Overpricing