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10.1371/journal.pone.0131730 http://scihub22266oqcxt.onion/10.1371/journal.pone.0131730 C4510130!4510130 !26197476     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26197476 &cmd=llinks): Failed to open stream: HTTP request failed! 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Association of Anti-GT1a Antibodies with an Outbreak of Guillain-Barré Syndrome and Analysis of Ganglioside Mimicry in an Associated Campylobacter jejuni Strain |pdf=|usr=}}{{26197476 }} gab.com Text Association of Anti-GT1a Antibodies with an Outbreak of Guillain-Barré Syndrome and Analysis of Ganglioside Mimicry in an Associated Campylobacter jejuni Strain JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26197476 #FOAvip An outbreak of Guillain-Barré syndrome (GBS), subsequent to Campylobacter jejuni enteritis, occurred in China in 2007. Serum anti-ganglioside antibodies were measured in GBS patients and controls. Genome sequencing was used to determine the phylogenetic relationship among three C. jejuni strains from a patient with GBS (ICDCCJ07001), a patient with gastroenteritis (ICDCCJ07002) and a healthy carrier (ICDCCJ07004), which were all associated with the outbreak. The ganglioside-like structures of the lipo-oligosaccharides of these strains were determined by mass spectrometry. Seventeen (53%) of the GBS patients had anti-GT1a IgG antibodies. GT1a mimicry was found in the lipo-oligosaccharides of strain ICDCCJ07002 and ICDCCJ07004; but a combination of GM3/GD3 mimics was observed in ICDCCJ07001, although this patient had anti-GT1a IgG antibodies. A single-base deletion in a glycosyltransferase gene caused the absence of GT1a mimicry in ICDCCJ07001. The phylogenetic tree showed that ICDCCJ07002 and ICDCCJ07004 were genetically closer to each other than to ICDCCJ07001. C. jejuni, bearing a GT1a-like lipo-oligosaccharide, might have caused the GBS outbreak and the loss of GT1a mimicry may have helped ICDCCJ07001 to survive in the host. Twit Text FOAVip Association of Anti-GT1a Antibodies with an Outbreak of Guillain-Barré Syndrome and Analysis of Ganglioside Mimicry in an Associated Campylobacter jejuni Strain ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26197476 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26197476 #FOAvip English Wikipedia <ref>{{Cite pmid|26197476 }}</ref> Association of Anti-GT1a Antibodies with an Outbreak of Guillain-Barré Syndrome and Analysis of Ganglioside Mimicry in an Associated Campylobacter jejuni Strain #MMPMID26197476 Zhang M ; Gilbert M ; Yuki N ; Cao F ; Li J ; Liu H ; Li Q ; Meng F ; Zhang J PLoS One 2015[]; 10 (7 ): e0131730 PMID26197476 show ga An outbreak of Guillain-Barré syndrome (GBS), subsequent to Campylobacter jejuni enteritis, occurred in China in 2007. Serum anti-ganglioside antibodies were measured in GBS patients and controls. Genome sequencing was used to determine the phylogenetic relationship among three C. jejuni strains from a patient with GBS (ICDCCJ07001), a patient with gastroenteritis (ICDCCJ07002) and a healthy carrier (ICDCCJ07004), which were all associated with the outbreak. The ganglioside-like structures of the lipo-oligosaccharides of these strains were determined by mass spectrometry. Seventeen (53%) of the GBS patients had anti-GT1a IgG antibodies. GT1a mimicry was found in the lipo-oligosaccharides of strain ICDCCJ07002 and ICDCCJ07004; but a combination of GM3/GD3 mimics was observed in ICDCCJ07001, although this patient had anti-GT1a IgG antibodies. A single-base deletion in a glycosyltransferase gene caused the absence of GT1a mimicry in ICDCCJ07001. The phylogenetic tree showed that ICDCCJ07002 and ICDCCJ07004 were genetically closer to each other than to ICDCCJ07001. C. jejuni, bearing a GT1a-like lipo-oligosaccharide, might have caused the GBS outbreak and the loss of GT1a mimicry may have helped ICDCCJ07001 to survive in the host. |Antibodies, Bacterial/blood/*immunology [MESH] |Antigens, Bacterial/blood/genetics/*immunology [MESH] |Campylobacter Infections/blood/epidemiology/*immunology [MESH] |Campylobacter jejuni/genetics/*immunology/metabolism [MESH] |Female [MESH] |Gangliosides/blood/genetics/*immunology [MESH] |Guillain-Barre Syndrome/blood/epidemiology/*immunology [MESH] |Humans [MESH] |Lipopolysaccharides/blood/genetics/immunology [MESH] |Male [MESH] |Molecular Mimicry/*immunology [MESH] |Phylogeny [MESH]Association of Anti-GT1a Antibodies with an Outbreak of Guillain-Barré(epmc).pdf DeepDyve Pubget Overpricing