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10.1016/j.molcel.2010.08.029 http://scihub22266oqcxt.onion/10.1016/j.molcel.2010.08.029 C4509788!4509788!20864041     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2010 ; 39 (6): 963-74 Nephropedia Template TP {{tp|p=20864041|t=2010. MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases |pdf=|usr=}}{{20864041}} gab.com Text MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=20864041 #FOAvip The melanoma antigen (MAGE) family consists of more than 60 genes, many of which are cancer-testis antigens that are highly expressed in cancer and play a critical role in tumorigenesis. However, the biochemical and cellular functions of this enigmatic family of proteins have remained elusive. Here, we identify really interesting new gene (RING) domain proteins as binding partners for MAGE family proteins. Multiple MAGE family proteins bind E3 RING ubiquitin ligases with specificity. The crystal structure of one of these MAGE-RING complexes, MAGE-G1-NSE1, reveals structural insights into MAGE family proteins and their interaction with E3 RING ubiquitin ligases. Biochemical and cellular assays demonstrate that MAGE proteins enhance the ubiquitin ligase activity of RING domain proteins. For example, MAGE-C2-TRIM28 is shown to target p53 for degradation in a proteasome-dependent manner, consistent with its tumorigenic functions. These findings define a biochemical and cellular function for the MAGE protein family. Twit Text FOAVip MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=20864041 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20864041 #FOAvip English Wikipedia <ref>{{Cite pmid|20864041}}</ref> MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases #MMPMID20864041 Doyle JM; Gao J; Wang J; Yang M; Potts PR Mol Cell 2010[Sep]; 39 (6): 963-74 PMID20864041show ga The melanoma antigen (MAGE) family consists of more than 60 genes, many of which are cancer-testis antigens that are highly expressed in cancer and play a critical role in tumorigenesis. However, the biochemical and cellular functions of this enigmatic family of proteins have remained elusive. Here, we identify really interesting new gene (RING) domain proteins as binding partners for MAGE family proteins. Multiple MAGE family proteins bind E3 RING ubiquitin ligases with specificity. The crystal structure of one of these MAGE-RING complexes, MAGE-G1-NSE1, reveals structural insights into MAGE family proteins and their interaction with E3 RING ubiquitin ligases. Biochemical and cellular assays demonstrate that MAGE proteins enhance the ubiquitin ligase activity of RING domain proteins. For example, MAGE-C2-TRIM28 is shown to target p53 for degradation in a proteasome-dependent manner, consistent with its tumorigenic functions. These findings define a biochemical and cellular function for the MAGE protein family. äMAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases (epmc).pdf DeepDyve Pubget Overpricing