Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26197779
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Public+Health
2015 ; 15
(ä): 691
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The LIFE-Adult-Study: objectives and design of a population-based cohort study
with 10,000 deeply phenotyped adults in Germany
#MMPMID26197779
Loeffler M
; Engel C
; Ahnert P
; Alfermann D
; Arelin K
; Baber R
; Beutner F
; Binder H
; Brähler E
; Burkhardt R
; Ceglarek U
; Enzenbach C
; Fuchs M
; Glaesmer H
; Girlich F
; Hagendorff A
; Häntzsch M
; Hegerl U
; Henger S
; Hensch T
; Hinz A
; Holzendorf V
; Husser D
; Kersting A
; Kiel A
; Kirsten T
; Kratzsch J
; Krohn K
; Luck T
; Melzer S
; Netto J
; Nüchter M
; Raschpichler M
; Rauscher FG
; Riedel-Heller SG
; Sander C
; Scholz M
; Schönknecht P
; Schroeter ML
; Simon JC
; Speer R
; Stäker J
; Stein R
; Stöbel-Richter Y
; Stumvoll M
; Tarnok A
; Teren A
; Teupser D
; Then FS
; Tönjes A
; Treudler R
; Villringer A
; Weissgerber A
; Wiedemann P
; Zachariae S
; Wirkner K
; Thiery J
BMC Public Health
2015[Jul]; 15
(ä): 691
PMID26197779
show ga
BACKGROUND: The LIFE-Adult-Study is a population-based cohort study, which has
recently completed the baseline examination of 10,000 randomly selected
participants from Leipzig, a major city with 550,000 inhabitants in the east of
Germany. It is the first study of this kind and size in an urban population in
the eastern part of Germany. The study is conducted by the Leipzig Research
Centre for Civilization Diseases (LIFE). Our objective is to investigate
prevalences, early onset markers, genetic predispositions, and the role of
lifestyle factors of major civilization diseases, with primary focus on metabolic
and vascular diseases, heart function, cognitive impairment, brain function,
depression, sleep disorders and vigilance dysregulation, retinal and optic nerve
degeneration, and allergies. METHODS/DESIGN: The study covers a main age range
from 40-79 years with particular deep phenotyping in elderly participants above
the age of 60. The baseline examination was conducted from August 2011 to
November 2014. All participants underwent an extensive core assessment programme
(5-6 h) including structured interviews, questionnaires, physical examinations,
and biospecimen collection. Participants over 60 underwent two additional
assessment programmes (3-4 h each) on two separate visits including deeper
cognitive testing, brain magnetic resonance imaging, diagnostic interviews for
depression, and electroencephalography. DISCUSSION: The participation rate was 33
%. The assessment programme was accepted well and completely passed by almost all
participants. Biomarker analyses have already been performed in all participants.
Genotype, transcriptome and metabolome analyses have been conducted in subgroups.
The first follow-up examination will commence in 2016.